Protein synthesis inhibitors

Question 1

What is the MOA of clindamycin?

Answer 1

binds to 50S subunit (can cause competitive competition with macrolides)

Question 2

Is Clindamycin bacteriostatic or cidal?

Answer 2

STATIC but cidal at high conc

Question 3

What are 3 MORs of clindamycin?

Answer 3

1) altered target sites
2) active efflux
3) low level resistance to macrolides

Question 4

What is the SOA of clindamycin?

Answer 4

GRAM POS AEROBES: MSSA, PSSP, group/viridans strep

ANAEROBES: bacteroides

Question 5

How is clindamycin administered?

Answer 5

IV or PO (good bioavailability/absorption)

Question 6

How is clindamycin eliminated?

Answer 6

liver (not HD)

Question 7

When do you use clindamycin?

Answer 7

anaerobic infections OUTSIDE CNS (like pulm, intraab, pelvic, diabetic foot, ulcer)
SSTIs
alternative

Question 8

What are the main adverse effects of clindamycin?

Answer 8

1) GI
2) C. diff inducer
3) hepatotoxicty

Question 9

What are the 3 macrolides?

Answer 9

erythromycin
clarithromycin
azithromycin

Question 10

What is the MOA of macrolides?

Answer 10

inhibit prot synth by binding to 50S subunit

Question 11

are macrolides time or conc dependent?

Answer 11

erythro and clathro - time dependent

azithro - conc dependent

Question 12

What are the MORs for macrolides?

Answer 12

1) efflux pump
2) altered target sites
3) cross resistance

Question 13

What is the macrolide SOA?

Answer 13

Gram pos: clarithro>erythro>azithro