Protein Synthesis Inhibitors

Question 1

Which protein synthesis inhibitors cross the placenta?

Answer 1

Macrolides
Clindamycin
Tetracycline
Aminoglycosides

Question 2

Why are Macrolides not very good with G- bacteria?

Answer 2

Enterbacterales release esterase to hydrolyze them

Question 3

What is the product of clarithromycin metabolism?

Answer 3

14-hydroxyclarithromycin

Question 4

What is the triple therapy for H.pylori?

Answer 4

Clarithromycin
Amoxicillin
Bosmuth (PPI)

Question 5

Mycobacterium avium complex is seen more in …….. patients

Answer 5

HIV

Question 6

What is the 4th macrolide and what is it used for?

Answer 6

Fidaxomicin ; VRCD (PMC)

Question 7

At which creatinine clearance level do we adjust the dose of clarithromycin

Answer 7

<30mL/min

Question 8

What do you give a patient with prosthetic valve going into surgery if penicillin is not an option?

Answer 8

Clindamycin

Question 9

What is the route of administration of tigecycline?

Answer 9

IV

Question 10

Why is chloramphenicol not used ?

Answer 10

Highly toxic

Question 11

Why is chloramphenicol not used on infants?

Answer 11

Newoborns dont have glucoronic acid used to inactivate chloramphenicol which results in gray baby syndrome

Question 12

How do you monitor aminoglycosides for nephrotoxicity?

Answer 12

Creatinine clearance level

Question 13

Route of administration of aminoglycosides

Answer 13

Oral & Topical & IV+IM & Inhaled

Question 14

Aminoglycosides are toxic to the ….th nerve

Answer 14

8

Question 15

Route of administration of streptomycin?

Answer 15

IM

Question 16

Route of administration of capreomycin

Answer 16

IM

Question 17

What is clindamycin derived from

Answer 17

Lindamycin (insert family name)

Question 18

What is the only protein synthesis inhibitor effective against p.aeruginosa ?

Answer 18

Tobramycin