Protein Synthesis Inhibitors

Question 1

Static or cidal??

Answer 1

Static (predominantly)

Question 2

Name the Drugs

Answer 2

Basic drugs:
Aminoglycosides
Macrolides
Tetracycline
Chloramphenicol

Other drugs:
Protein loss FM

Question 3

What are the other drugs that come under protein synthesis inhibitors?

Answer 3

Protein- Pleuromutilins , Puramycin
L- Lincosamides
O- Oxazolidinones
S- Sordarin, Spectinomycin
S- Streptogramins
F- Fusidic acid
M- Mupirocin

Question 4

Name some Pleuromutilins

Answer 4

Retapamulin
Lefamulin

Question 5

Name some Lincosamides

Answer 5

Clindamycin
Lincomycin

Question 6

Name the Oxazolidinones

Answer 6

Linezolid

Question 7

Name some streptogrammins

Answer 7

Dalfopristin
Quinopristin

Question 8

Name the drugs which target 30S subunit of ribosome

Answer 8

” Pick oats TDS”
O- Oxazolidinones
A- Aminoglycosides
T- tetracycline
S- Spectinomycin

Question 9

MOA of Oxazolidinones

Answer 9

Binds and inhibits
1) 30s
2) 50s
3) 30s- 50s junction

Question 10

Name the protein synthesis inhibitors which are bactericidal

Answer 10

Aminoglycosides
Sordarin ( fungicidal)
Macrolides at high doses
Retapamulin at high doses
Dalfopristin and quinopristin combination