Protein Structure And Function

Question 1

What is the definition of protein?

Answer 1

Long chain of covalently linked amino acids

Linked together via a polypeptide bond

Question 2

What dictates the non-covalent bonds?

Answer 2

The different amino acid side chains

Question 3

The covalent bonds gives the chain ______ and _____

Non covalent bonding _________ ______

Answer 3

Flexibility and rotation

Maintains shape

Question 4

What pushes hydrophobic molecules together and arranges proteins into compact conformations?

Answer 4

Hydrophobic forces

Question 5

What helps the protein fold correctly and bind to the correct proteins?

Answer 5

Molecular chaperones

Question 6

Improperly folded proteins result in what?

Answer 6

Alzheimer’s ( protein aggregates that form beta amyloid plaques)

Huntington’s (inclusion bodies are formed)

Creuzfeld-Jakobs disease (infectious protein (prion disease))

Parkinson’s (lewey bodies formed, aggregate into amyloid fibrils)

Question 7

What are the three folding patterns?

Answer 7

Alpha helix

Beta sheets

Hydrogen bonding

Question 8

What are the four different levels of protein organization?

Answer 8

Primary

Secondary

Tertiary

Quaternary

Question 9

What makes up a primary structure?

Answer 9

Amino acid sequence

Question 10

What makes up a secondary structure of protein?

Answer 10

Alpha helix and beta sheets

Question 11

What makes up a tertiary structure?

Answer 11

Polypeptide with alpha helixes, beta sheets and random coils

Folded proteins