protein structure Flashcards

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1
Q

draw the structure of an amino acid

A

from flashcard

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2
Q

what are the 4 different groups on an amino acid ?

A
  • amine group
  • carboxyl group
  • hydrogen group
  • variable group
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3
Q

how many options are there for the R group ?

A

20

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4
Q

what kind of bond is formed between 2 amino acids during a condensation reaction ?

A

a peptide bond

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5
Q

Draw how 2 amino acids are joined together

A

from notes

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6
Q

what is a protein ?

A

proteins are polymers, made up of the monomer : amino acids

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7
Q

how many different amino acids are there ?

A

20

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8
Q

how is a polypeptide chain created ?

A

when more amino acids are added to a dipeptide

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9
Q

what is the molecule called when a peptide forms between 2 amino acids ?

A

the molecule is called a dipeptide

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10
Q

what are the different levels of structure in a protein ?

A
  • primary structure
  • secondary
  • tertiary
  • quaternary
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11
Q

what is meant by the primary structure of a protein ?

A

it is the order / sequence of amino acids in the polypeptide chain

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12
Q

what is meant by the secondary structure of a protein ?

A

when the sequence of amino acids causes parts of a protein molecule to bend into an alpha helix shape or a beta pleated sheet.

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13
Q

draw the structure of an alpha helix shape

A

notes

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14
Q

draw the structure of a beta pleated sheet

A

notes

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15
Q

how are the structures of the secondary protein held together ?

A

hydrogen bonds hold the secondary structures shape

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16
Q

where do the hydrogen bonds form in the secondary structures ?

A

hydrogen bonds form between the C=O groups of the carboxyl group of one amino acid and the H in the amine group of another amino acid

17
Q

what is the tertiary structure of a protein ?

A
  • the further folding of the secondary structure
  • to form a unique 3D shape
  • held in place by ionic, hydrogen and disulfide bonds
18
Q

where do the ionic and disulfide bonds form ?

A

they form between the R groups of different amino acids

19
Q

when do disulfide bonds occur ? and why ?

A

they only occur sometimes
because there must be a sulfur in the R group for the bond to occur

20
Q

where do hydrogen bonds form in a protein ?

A

hydrogen bonds form between all levels of the structure

21
Q

where do hydrophobic interactions occur in a protein ?

A

they occur between non-polar sections of the protein

22
Q

where do disulfide bonds occur in a protein ?

A

they occur between 2 cysteine amino acids

23
Q

name the bonds in the tertiary structure in order of weakest to strongest ?

A

hydrogen bonds
ionic bonds
disulfide bonds

24
Q

state the molecular formula of cysteine

A

CH2SH

25
Q

what is meant by the quaternary structure of a protein ?

A

a protein made up of more than 1 polypeptide chain

26
Q

what is an example of a quaternary structure of a protein ?

A

haemoglobin
- it has 4 polypeptides

27
Q

what happens to the bonds if the protein is denatured ?

A

it means that the bonds which hold the tertiary and secondary structure (ionic and hydrogen bonds break ) in shape break and therefore the unique 3D shape is lost

28
Q

what are conditions that may denature a protein ?

A
  • too high temperature
  • too high/too low pH (too many H+ or OH-)
29
Q

state the importance of the primary structure.
and what impact will that have on an enzyme ?

A

if even one amino acid in the sequence is different it will cause the ionic/hydrogen/disulfide bonds to form in a different location
which will result in a different 3D shape
so in enzymes, they will have a different shaped active site and so will be non-functioning

30
Q

specific function is due to what ?

A

specific function is due to the specific shape

31
Q

what can a functional protein contain ?

A

it may contain one or more polypeptides