Protein structure Flashcards
what is the primary structure
The sequence of amino acids
what is the secondary structure
The folding or coiling of an amino acid chain, due to hydrogen bonding.
Forms a a-helix or a B-pleated sheet
what is the tertiary structure
3D shape of the molecule, has a very precise shape
what is the quaternary structure
when a protein consists of more than one polypeptide chain
What part of a cell determines the primary structure
DNA, nucleus
Describe the alpha helix
held by H bonds
Amino acids per 10 turns of the helix
describe the b-pleated sheet
chains fold slightly in a zig zag structure
In the a-helix and b-pleated sheet, what parts of the amino acid do the hydrogen bonds bind to
The hydrogen bonds are between the amine group (-NH2) and the carboxyl group (-COOH) of another amino acid
What bonds are involved in the primary structure
Only peptide bonds
What bonds are used in the secondary structure
Peptide
Hydrogen
What bonds are used in the tertiary structure
Peptide
Disulphide
hydrogen
ionic
hydrophobic interactions
How does hydrophobic interactions make the amino acid spiral
The hydrophobic R groups associate with the centre of the polypeptide chain to avoid water exposure.
Hydrophilic parts of the amino acid are found at the edge of the polypeptide
Interactions of both cause amino acid chain to spiral