Protease Inhibitors Flashcards
All class SE
GI intolarance, wt gain, hyperglycemia, hyperlipidemia (avoid lovastatin and simvastatin), lipodystrophy, incr risk of MI, Bleeding (esp w/ Atazanavir, Darunavir, Fosamprenavir)
- take with food except Indinavir and Fosamprenavir susp form
- all go to liver; do not use with Rifampin
IDV
Indinavir (Crixivan)
kidney stone (nephrolithiasis), empty stomach, drink 1.5L/day, acid reflux (use Zantac)
sensitive to moisture; store in original bottle; wo dessicant, good for 3 days
LPV+ RTV
Lopinavir/Ritonavir (Kaletra) alcohol 42% tablet- regardless of food (200/50) solution -with food to enhance absorption; in fridgel; 2 mos if store at RT. cause severe migraine and pancreatitis.
NPV
Nelfinavir (Viracept)
come in powder; stable for 6 hr after mix if refrigerated.
bad diarrhea-tx with Imodium or Lomotil
NVP = navirapine (Viramune)-NNRTI
RTV
Ritonavir (Norvir) 600 mg (6 caps) bid alcohol ritonavir tab-RT; 2 wks stable if outside original container Ritonavir cap - in frid; 30 days for RT Ritonavir solution- shelf Ritonavir + lopinavir solution- in frid Ritonavir + Lopinavir tab - shelf SE: numbness; highest hyperlipidemia.
SQV
Saquinavir (Invirase)
contain lactose
life treatehing cardiac effects when use with Ritonavir (use within 2 hours of food)
TPV
Tipranavir (Aptivus)
contains alcohol, sulfa allergy
BBW: Intracranial hemorrhage; fatal hepatotoxicity
refrig caps b4 opening; 60 days at RT
FPV
Fosamprenavir (Lexiva)
sulfonamide allergy
avoid PPI and H2RA blockers to prevent treatment failure.
Fosamprenavir soln-empty stomach.
ATZ
Atazanavir (Reyataz) dose QD; does not affect lipid prolong PR, cause AV block CI: Indavir (incr bilirubin); Viread (Reyataz incr Viread level; Viread decr Reyataz) AZT: Zidovudine (Retrovir)-NRTI
Darunavir
Prezista
must be taken with ritonavir
Heperlipidemia, hepatitis, sulfa allergy
drugs contain sulfa
Tipranavir (Aptivus)
Fosamprenavir (Lexiva)
darunavir (Prezista)
drugs contain alcohols
Kaletra
Ritonavir
Tipranavir
