Other meds

Question 1

Sezlentry

CCR5

Answer 1

Maraviroc
must combine with other HIV meds
hepatoxicity, heart problem, URTI, orthostatic hypoTN
-with inhibitors (azole, PI excp Tipranavir/Ritonavir, clarithromycin, nefazadone, Telithromycin): 150 mg PO BID
-with all NRTIs, Tipranavir/Ritonavir, Nevirapine, Enfuvirtide: 300 mg BID
-with inducers (incl Enfavirenz): 600 mg BID

Question 2

Enfuviritide

Answer 2

Fuzeon
entry inhibitors gp120-41
90 mg SC BID
hypersensitivity, cause pneumonia/infection.

Question 3

Raltegravir

Answer 3

Isentress
Integrase inhibitor; must use in combo
for tx experienced patients who have HIV strains that are resistant to mulitple drugs
400 mg BID
SE: diarrhea, N, HA, increase CPK (myopathy and rhabdomyolysis)