Nucleoside Reverse Transcritptase Inhibitors (NRTI's)

Question 1

ABC

Answer 1

Abacavir (Ziagen)
HLB-5701
300 mg bid

Question 2

Trizivir

Answer 2

zidovudine (AZT, ZDV) + Abacavir (ABC) + lamivudine (3TC)

Question 3

ddl

Answer 3

Didanosine (Videx, Videx EC)
empty stomach, eye exam q6-12 months.
pancreatitis, reinal pigmentation, peripheral neuropathy
buffered tab = Mg antacid; EC = no Mg

Question 4

3TC

3 thang trung cong

Answer 4

Lamivudine (Epivir, Epivir-HBV)
Epivir-150 mg BID
Epivir- HBV 100 mg QD x 1 yr
Similar structure to Emtricitabine

Question 5

d4T

Answer 5

Stavudine (Zerit)
30 days stable at frid after reconstit.
separate from antacids and didanosine by 1 hr
pancreatitis, per, neuropathy, lipodystrophy

Question 6

AZT, ZDV

Answer 6

Zidovudine (Retrovir) cap
the only HIV drug come in IV
used in pregnancy
take with food to dcr nause
mylosuppression (anemia, neutropenia)
purple toe nails
lactic acidosis and hepatic steatosis (class SE)

Question 7

FTC

Answer 7

Emtricitabine (Emtriva)
structure similar to Lamivudine (Epivir)
for child > 3mos
flare up of Hep b start; used to tx Hep B
darkening of palms and soles after 3m used

Question 8

ddl , d4T

Answer 8

didanosine, Stavudine
peripheral neuropathy
pancreatitis

Question 9

NRTI class se

Answer 9

lactic acidosis
HA
can take w or wo food except ddl-empty, zidovudine-with food
all renal eliminated
Stavudine and Didanosine cause peripheral neuropathy and pancreatitis

Question 10

TNV, TDF

Answer 10

Tenofovir (Viread)
HIV 1 for >2yr
chronic Hep B >12 yr
risk of osteoporosis; consider Ca + vit D
Acute renal failure; Fanconi syndrome