Prostrate Cancer Flashcards

1
Q

What is a prostate?

A

The prostate is a gland. It is usually the size and shape of a walnut and grows bigger as you get older. It sits underneath the bladder and surrounds the urethra. This is the tube that carries urine out of the body. The prostate is designed to help make semen – the fluid that carries sperm

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2
Q

What percent of men suffer with prostate cancer at some point in their lives ?

A

1/8 12.5%- most common cancer in men in the UK

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3
Q

Which age group does prostrate cancer mainly affect ?

A

Over 50 years old. The average for men to be diagnosed is between 65-69 years and

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4
Q

What are the risk factors for prostate cancer?

A

. Family history - men with father or brother diagnosed with prostrate cancer are 2.5x more likely to get it

. Ethnicity- black men are at highest risk of prostrate cancer. 1/4 men suffer from it at some point in their lives.

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5
Q

What is early prostrate cancer?

A

Early prostate cancer is confined within the capsule and rarely causes symptoms.

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6
Q

What is locally advanced prostrate cancer?

A

Locally advanced prostate cancer extends beyond the capsule of the prostate and is often asymptomatic when diagnosed.

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7
Q

What is metastatic prostrate cancer and what are the symtomps ?

A

Metastatic/ advanced cancer that has spread from the prostate to other parts of the body.
most frequently affects the bones, where it causes symptoms such as:

Bone pain, Fatigue, Feeling generally unwell, Unexplained weight loss, and Coughing or shortness of breath if the cancer has spread to the lungs.

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8
Q

When do symptoms of prostrate cancer typically begin and state them

A

When the prostrate is large enough to affect the urethra.

Symptoms include:

. Increased urgency to urinate
. Straining while you pee
. The feeling that your bladder has not fully emptied
. Blood in urine

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9
Q

Other than prostrate cancer, what are two other prostrate problems ?

A

. Enlarged prostrate

. Prostatitis - inflamed prostrate

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10
Q

What age is an enlarged prostrate most common in men and what can this cause to happen ?

A

. Most common in men over 50

. Causes change in urination

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11
Q

What test is usually first done to test for prostrate cancer?

A

PSA ( blood test) that measures the presence of Prostate-specific antigen circulating in your bloodstream.

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12
Q

What is the disadvantage of a blood PSA?

A

Low sensitivity - blood PSA is an inaccurate test for prostate cancer because cancer can be present without increased PSA levels, and PSA levels may be increased by conditions other than cancer (such as benign prostatic enlargement, prostatitis, and urinary tract infection).

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13
Q

What is watchful waiting and who is it aimed at?

A

Watchful waiting is aimed at people with localized prostate cancer who are either not suitable for, or do not wish to receive treatment, and instead involves the deferred use of hormone therapy.

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14
Q

What is active surveillance and what does it involve?

A

Active surveillance is a method of monitoring a patient with localised (early) prostatic cancer as prostrate cancer tends to grow slowly . The goal is to delay treatment until it’s necessary. Active surveillance involves :

-Regularly monitoring the patient’s condition with tests like blood tests, imaging tests, and biopsies
Waiting for changes in test results to indicate that the condition is worsening

-Avoiding or delaying treatment options like surgery or radiation therapy

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15
Q

Treatment: what is radical prostatectomy?

A

The surgical removal of the entire prostrate gland and lymph nodes. This can be done by an open approach or keyhole technique (making a small incision)

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16
Q

Treatment: what is external beam radiography ( EBRT)

A

External beam radiography: is radiotherapy given by using ionizing radiation (for example, high-energy X-rays) produced in a machine and directed at the tumour from outside the person. This kills and shrinks tumours.

17
Q

Treatment: what is Brachytherapy

A

Brachytherapy is a type of radiotherapy in which the radiation is given using either permanently implanted radioactive seeds (low dose rate) or temporarily inserted radioactive sources (high dose rate) directly into the prostate.

18
Q

How can elevated levels of the hormone androgen cause prostrate cancer?

A

Androgens bind to androgen receptors in prostate cancer cells, which stimulates the expression of genes that cause the cells to grow.

19
Q

Whats an example of a hormonal treatment used to treat prostrate cancer ?

A

Androgen deprivation therapy (ADT) is a hormonal treatment for prostate cancer that reduces the amount of androgens, or male hormones such as testosterone in the body.

20
Q

What are three examples of androgen deprivation therapy?

A

. Surgery- removing testicles to reduce testosterone production

. Taking antiandrogens: These drugs block the action of androgens in the body.

. Taking androgen synthesis inhibitors: These drugs block the production of androgens throughout the body, including in the testicles, adrenal glands, and prostate cancer cells.

21
Q

What is hormone-relapsed metastatic disease and how is it treated?

A

Hormone-relapsed metastatic prostate cancer (also known as metastatic castration-resistant prostate cancer) is a cancer that has spread beyond the prostate and no longer responds to androgen deprivation therapy (ADT). This type of prostatic cancer requires chemotherapy to treat.

22
Q

Whats an example of two chemotherapy drugs that are commonly used to treat cancer.

A

Docetaxel in combination with prednisolone : licensed for hormone-resistant metastatic prostate cancer.

23
Q

Treatment: what are biphosphonates and how do they work in treating cancer; when are they used?

A

Bisphosphonates are calcium-regulated drugs which inhibit bone resorption (biome tissue being broken down) , used in the treatment of hypercalcemia, osteoporosis (low bone mass) , and bone pain.

Bisphosphonates should be offered to people who are having androgen deprivation therapy and have osteoporosis.

24
Q

When should men with prostrate cancer be referred despite receiving current treatment?

A

Refer men with evidence of significant disease progression (rapidly rising PSA level or bone pain) to a urological cancer specialist.

25
Q

What can be some adverse effects of androgen withdrawal ?

A

Adverse effects of androgen withdrawal include change in body shape and weight gain, tiredness, hot flushes, loss of libido.