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Q

PCa Pharm

LHRH Agonist vs Antagonist

A

Agonist
* Leuprolide (Lupron)
* Goserelin (Zoladex)
* Triptorelin (Trelstar)

Antagonist
* Degarelix (Firmagon)
* Relugolix (Orgovyx)

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Q

PCa Pharm

Enzalutamide

A

3rd Generation androgen receptor antagonist
Xtandi

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Q

Pca Pharm

Abiraterone acetate

A

CYP-17 inhibitor
Leads to decreased cortisol production
Should be taken with prednisone to prevent accumulation of mineralocorticoids (increased corticosterone)

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Q

PCa Pharm

Olaparib

A

PARP inhibitor

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Q

PCa Pharm

Pembrolizumab

A

PD-1
Indicated in mismatch repair-deficiency and microsatellite instability high

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