Prostate Pathology Flashcards
high grade prostatic intraepithelial neoplasia (HGPIN)
precursor to invasive prostatic cancer
does not increase PSA itself
if PSA is elevated and this is seen on biopsy, there is a 25-30% chance of prostatic cancer if repeat biopsy is done
prostatitis that can be infectious from tuberculosis or fungal
can be non-infectious following BCG treatment for bladder cancer
Granulomatous prostatitis
usually seen in younger men due to reflux from the lower urinary tract, (E. coli, P. aeruginosa, K. pneumoniae)
characterized by pain, fever, and tenderness on rectal exam
Acute prostatitis
Granulomatous prostatitis
prostatitis that can be infectious from tuberculosis or fungal
can be non-infectious following BCG treatment for bladder cancer
1 cancer diagnoses and #2 in cancer deaths in US
1 in 6 lifetime chance
PSA is marker
almost always occurs in the peripheral zone
spreads to seminal vesicles, external iliac nodes, metastasizes to pelvic bones and vertebra
graded using the Gleason score
prostatic adenocarcinoma (prostate cancer)
Chronic prostatitis
bacteria cause is usually from recurrent acute prostatitis
abacterial cause accounts for 95% of prostatitis
causes a chronic pain syndrome
may be caused by atypical organisms like mycoplasma, ureaplasma, trichomonas
a proliferation of the gland and stroma in the transitional zone of prostate
causes bladder outlet obstruction (BOO) involving urinary frequency, incomplete emptying, nocturia, dysuria
90% prevalence by age 80 androgen-dependent process, chiefly caused by DHT
PSA can be mildly elevated
benign prostatic hyperplasia
benign prostatic hyperplasia
a proliferation of the gland and stroma in the transitional zone of prostate
causes bladder outlet obstruction (BOO) involving urinary frequency, incomplete emptying, nocturia, dysuria
90% prevalence by age 80 androgen-dependent process, chiefly caused by DHT
PSA can be mildly elevated
bacteria cause is usually from recurrent acute prostatitis
abacterial cause accounts for 95% of prostatitis
causes a chronic pain syndrome
may be caused by atypical organisms like mycoplasma, ureaplasma, trichomonas
Chronic prostatitis
prostatic adenocarcinoma (prostate cancer)
1 cancer diagnoses and #2 in cancer deaths in US
1 in 6 lifetime chance
PSA is marker almost always occurs in the peripheral zone
spreads to seminal vesicles, external iliac nodes, metastasizes to pelvic bones and vertebra
graded using the Gleason score
Acute prostatitis
usually seen in younger men due to reflux from the lower urinary tract, (E. coli, P. aeruginosa, K. pneumoniae)
characterized by pain, fever, and tenderness on rectal exam
precursor to invasive prostatic cancer
does not increase PSA itself
if PSA is elevated and this is seen on biopsy, there is a 25-30% chance of prostatic cancer if repeat biopsy is done
high grade prostatic intraepithelial neoplasia (HGPIN)
