Prostate Cancer

Question 1

Risk Factors for

Answer 1

• Age
• Family History
• Race/National Differences
• Hormones
• Meat & Dairy
• Precursor Lesion: High Grade Prostatic Intraepithelial Neoplasia (PIN)

Question 2

High grade prostatic intraepithelial neoplasia (PIN):

- differences from carcinoma?

Answer 2

1. Large glands
2. With basal cells

Desc: Large glands with intraluminal proliferation of atypical epithelial cells (dysplasia)

Question 3

a) 75% of prostate carcinoma in the ____ zone
b) 20% of prostate carcinoma in the ____ zone
c) 5% of prostate carcinoma in the ____ zone

Answer 3

a) peripheral
b) transition
c) central

Question 4

Diagnostic Tissue Markers for Prostatic Adenocarcinoma?

Answer 4

Basal cell markers: high molecular weight cytokeratin (34BE12) and p63.

Tumor marker: α-Methylacyl-CoA Racemase (AMACR)/P504S

Question 5

a) Inc’d Free PSA = ?

b) Complexed PSA: ?

Answer 5

a) Benign

b) Malignant

Question 6

Which Gleason Grade is the most common pattern?

Answer 6

Gleason Grade 3

• Infiltrative manner (growth between benign glands)
• Small Cribriform pattern

Question 7

Gleason Grade?

Fused glands without intervening stroma.

Answer 7

Gleason Grade 4

Question 8

Common local metastatic sites for Prostate spread?

Answer 8

• Seminal vesicle invasion

- Bladder and rectal invasion (less common)

Question 9

Most frequent sites for distant metastatic spread of Prostate cancer?

Answer 9

Regional lymph nodes

Bone metastases