Prostate Ca

Question 1

What part of the prostate do tumors mostly occur

Answer 1

Peripheral zone> transitional zone> central zone

Question 2

What is the main histological appearance of prostate cancer

Answer 2

Adenocarcinoma

Question 3

Clinical features of prostate cancer

Answer 3

NB ONLY ADVANCED DISEASE SHOWS SYMPTOMS

Features of advanced disease: 
Features of urinary obstruction
Pelvic pain
Hematuria 
Post renal failure 
Erectile dysfunction

Mets: bone mets so none pain and arthritis and features of anemia and pancytopenia
Mets tovisceral organs less common but lungs liver and adrenals most

Question 4

Classical finding on dre of a patient with prostate cancer

Answer 4

Stony hard prostate in part or whole of the gland with obliteration of median sulcus

Question 5

Where is the most common site of origin of skeletal mets

Answer 5

Prostate

Question 6

What psa values suggests cancer and what suggests advanced disease and basically diagnostic of prostate cancer

Answer 6

So a psa of more than 10 is suggestive of cancer

However more than 35 is almost diagnostic

Question 7

Imaging modality of choice for staging local disease of prostate cancer

Answer 7

Mri

Question 8

If psa levels are above 10 what’s a necessary investigation that must be done

Answer 8

Once diagnosis made bone scan must be performed if psa above 10 or biopsy shows high grade cancer