PROLOG: Obstetrics Flashcards
HPV Vaccine Administration

Why is pregnancy a hypercoagulable state? (4)
- Increased venous stasis
- Decreased venous outflow
- Compression of IVC by the uterus
- Decreased mobility
Which coagulation factor is decreased in pregnancy?
Protein S
What is the most common structural malformation associated with increased nuchal translucency?
Cardiac septal defects
A fetus identified has having an increased nuchal translucency and possible cardiac defect should be assessed with 1T Doppler of the DV and 2T Echo
How to diagnose fetal hemoglobinopathies?
Genetic testing: Mutations found in the parents can be used to identify the mutation in the fetus
The DNA-based tests can be performed using chorionic villi obtained by CVS at 10-12 weeks gestation or using cultured amniotic fluid cells obatined by amniocentesis after 15 weeks
What is APA associated with?
Increased risk of having a child with a single-gene disorder (achondroplasia, Apert syndrome, Crouzon syndrome)
Increased risk mainly due to an increased incidence of gene mutations that occur with spermatogenesis as a man ages
What is the MOST common aneuploidy associated with cystic hygroma in 2T?
Turner Syndrome (45X)
Other findings: coarctation of the aorta, shield-shaped chest, short stature
What is the MOST common cause of cystic hygroma in 1T?
Down Syndrome
Noonan syndrome associated findings
Pectus excavatum, pulmonary stenosis, short limbs
Edwards syndrome associated findings
Microcephaly, micrognathia, and short, overlapping digits

What complication has amnioinfusion been shown to reduce?
Cesarean delivery
What is the most common thrombophilic gene mutation in pregnancy?
Factor V Leiden heterozygote, responsible for 40% of all VTEs during pregnancy
When should zidovudine infusion begin prior to a cesarean delivery?
3 hours preoperatively in women with viral loads at time of delivery are greater than 1,000 copies/mL
ACOG Recommendations for HIV-Positive Patients

Which of the following is MOST associated with fetal surgery for repair of myelomeningocele?
Lower rates of VP shunts (40% vs 82%)
MRI Findings after Eclampsia

Induction of Labor for Fetal Demise with Previous C/S

What is the goal of internal rotation of the fetus?
Allow turning of the fetal head so that the occiput gradually moves toward the pubic symphysis and away from a transverse axis
What is the most common cause of maternal death in the first trimester?
Ectopic pregnancy
Risk factors for ectopic pregnancy

How is diagnosis of APS made?
Presence of at least 1 clinical criterion and at least 1 antibody that is persistently elevated 12 weeks apart

Antibiotic regimen for a woman with anaphylaxis to penicillin admitted for threatened PTL with intact membranes at 34 weeks’ gestation
Vancomycin, 20 mg/kg IV every 8 hours until delivery
Antibiotic regimen for GBS ppx based on allergy status
No PCN allergy
PCN allergy wth low risk for anaphylaxis
PCN allergy with high risk for anaphylaxis

Pregnancy is within GA range of 9+0 to 13+6 weeks, the pregnancy should be redated if the discrepancy between US and LMP dating is ___.
More than 8 days











































































