Prolactin producing adenomas Flashcards
1
Q
fancy name
A
adenohypophyseal lactotrophs
2
Q
common presentation in women vs men
A
women: younger, smaller, less prolactin, ~400 ng/ml
amenorrhea, galactorrhea
men: opposite, impotence and dec. libido ~2000 ng/ml
3
Q
prepubertal/elderly presentation
A
mass effect
4
Q
what is stalk compression
A
mass effect on stalk blocks dopamine from inhibiting prolactin release; result: increased prolactin ~100 ng/ml
5
Q
gross appearance?
A
soft, red-tan
6
Q
histological appearance?
A
monomorphic, sheet-like, sparsely granulated
psammoma bodies and/or amyloid deposits
7
Q
genetic factors? IHC stain?
A
MEN-1 & immunoperoxidase
