Progestins Flashcards
Progesterone is a precursor hormone to:
estrogens, androgens, and corticosteroids
Progesterone is produced by: (2)
corpus luteum and placenta
4 synthetic progestin 21-C hormones:
hydroxyprogesterone
medroxyprogesteron
megestrol
dimethisterone
Do 3rd generation progestins have higher or lower androgenic activity?
lower
Name three 3rd gen progestins.
desogestrel
gestodene
norgestimate
Is progesterone eliminated by the kidneys or liver and how?
Liver, 1st pass, eliminated as pregnanediol glucuronide
Does progesterone bind PRE as a homodimer or heterodimer?
BOTH :P
How would you describe Progesterone receptors
A&B splice variant intracellular hormone receptors
Differences in binding between Synthetic 21-C and 19-nortestosterone derivate progestins
21-C bind aldosterone receptor and antagonize aldosterone- induced NA+ retention
19- produce decidual changes in endometrial stroma
Progestins without androgenic activity?
desogestrel
gestodene
norgestimate
(3rd gen)
Dimethisterone, norethindrone, and desogestrel do not:
produce increased ventilatory response to CO2 at the respiratory center.
A larger parenteral dose of medroxyprogesterone induced:
prolonged anovulations and amenorrhea
Medroxyprogesterone is used to treat:
dysmenorrhea, endometriosis, bleeding disorders and for contraception
What can be used to treat precocious puberty (prevent menstruation) without causing premature epiphysial closure.
medroxy-progesterone
If progesterone withdrawal causes withdrawal bleeding in patients with amenorrhea what can it prove?
The that patient is secreting estrogen normally despite amenorrhea.
