Progesterone

Question 1

Progesterone secreted by

Answer 1

Corpus luteum

Question 2

Classify synthetic progestins

Answer 2

1st Generation (Estranes)
Norethindrone Norethinodrel Lynestrenol

2nd Generation (Gonanes)
Norgestrel Levonorgestrel

3rd Generation Desogestrel
Norgestimate Gestodene

4th Generation Nomegestrol Drospirenone

Question 3

Uses of progestin

Answer 3

Oral contraceptives
HRT
decrease risk of endometrial and ovarian cancer

Question 4

Use of Drospirenone preferred in which individuals

Answer 4

Drospirenone possess aldosterone receptor antagonistic activity; preferred In woman who have fluids retention after taking OCP

Question 5

Uses of MIFEPRISTONE

Answer 5

M - Morning after pill
I - Induction of abortion
F - Fibroid
E - Endometnosis
P - Progesterone
R - Receptor +ve breast cancer and meningioma
I -Increased
S - Steroids (Cushing)
TONE

Question 6

Examples of SPRM drugs

Answer 6

Mifepristone
onapristone
ulipristal
Asoprisnil

Question 7

Decreasing Order of progesterone antagonistic activity in SPRM drugs

Answer 7

Onapristone
Mifepristone
Ulipristal (partial agonist)

Question 8

Most commonly used progesterone in combined OCP

Answer 8

LNG

Question 9

Combined OCP classification based on estrogen amount

Answer 9

Standard 50ug
Low 30-35ug
Very low 20ug

Question 10

Elaborate contents of monophasic, biphasic and triphasic OCPs

Answer 10

Monophasic: Content of estrogen and progesterone remain same in all the pills (for 21 days).
Biphasic: Content of progesterone is different in pills for first 10 days and that for 11-21 days
Triphasic: Content of progesterone is gradually
increased. It is lowest in first phase (l-6 days), moderate in second phase (7-11 days) and further increased in third phase (12-21 days)

Question 11

Major mechanisms of different OCPs

Answer 11

combined OCP Inhibit ovulation
Mini pills Cervical mucus thickening
Emergency contraceptives inhibit implantation

Question 12

OCPS are contraceptives of choice for

Answer 12

OCPs are contraceptives of choice
for Newly married couples
After evacuation of molar pregnancy

Question 13

Minipills are oral contraceptives of choice for

Answer 13

Minipills are oral contraceptives of choice for lactating women
Sickle cell anemia
Seizure disorder

Question 14

X contain low dose of progestins without any estrogen. X are less effective than combined OCPs. Identify X.

Answer 14

Minipills

Question 15

Minipills are preferred in women where estrogen is contraindicated; for example…

Answer 15

Smokers
>35 years of age
Risk factors of thromboembolism

Question 16

Examples of parenteral contraceptives with route of administration

Answer 16

DMPA and NETEN Intramuscular
Norplant and Capranor subcutaneous
Implanon and uniplant subcutaneous

Question 17

Breast and cervical carcinoma risk increased and endometrial and ovarian carcinoma risk decreased by use of

Answer 17

OCP

Question 18

List out the non contraceptive benefits of OCPs

Answer 18

Ovarian cyst
Benign breast disease
Ectopic pregnancy
Neoplasia (Ovarian, Endometrial, Colon cancer) Endometriosis
Fibroid
Iron deficiency anem1a
Tension (Pre-menstrual tension syndrome)
Skeletal (RA and Osteoporosis)

Question 19

List out the adverse effects of OCP

Answer 19

Migraine
Edema
Nausea
Mastalgia
Failure of withdrawal bleeding
Breakthrough bleeding
Weight gain
Hirsutism and acne
Venous thromboembolism
Cholestatic jaundice
Gall bladder disease
Hepatic adenine
Breast and cervical carcinoma

Question 20

To allow withdrawal bleeding during combined OCP regime, X tablets are given. Identify X

Answer 20

Iron tablets