Androgens and Anti Androgens

Question 1

Testosterone is converted to DHT by X and to estradiol by Y.
Identify X and Y

Answer 1

Testosterone is converted to DHT by 5-a reductase and to estradiol by aromatase.

Question 2

X indicated for hygonadal men to compensate for decreased endogenous secretion. State X and its adverse effect

Answer 2

X is Testosterone enanthate (im and id routes)
May cause liver adenoma and carcinoma
Polycythemia and hypertension may also occur

Question 3

List out uses of androgens

Answer 3

Hypogonadal men
To reduce breast engorgement during Post partum period
Chemotherapy of breast tumours in premenopausal women
Abused by athletes
Stimulate growth in boys with delayed puberty
Treatment of osteoporosis

Question 4

List out adverse effects of androgens

Answer 4

Masculinising action in females
Increased risk of atherosclerosis
Masculinisation of female fetus and under masculinisation of male fetus
Sodium retention and Edema
Cholestatic jaundice and peliosis hepatica
Acne gynecomastia and azoospermia

Question 5

Major use of Danazol

Answer 5

Treatment of endometriosis

Question 6

Classify anti androgens based on mechanisms of action

Answer 6

Steroid synthesis inhibitors: Ketoconazole Abiraterone
5 alpha reductase inhibitors: Finasteride and dutasteride
Androgen receptor antagonists: cyproterone, cyproterone acetate, Spironolactone

Question 7

Spironolactone competes with …….. for its receptor

Answer 7

DHT