Prof Jackson Flashcards
How would you synthesis this molecule?
React the carbonyl with NaCN in H2O/HCl conditions
How would you synthesis this molecule?
with Hydride Ion NaBH4 , this is followed by an acid work up.
Besides NaBH4 how else can this be synthesised
Using organolithium reagents and Grignard reagents. This is followed by an acid work up
How are organolithium reagents made?
Reacting R–X with Li and THF( tetrahydrofuran) which gives R-Li and Li-X
How are grignard reagents made?
R-X is reacted with MG/Et2O
How can aldehydes and ketones be made from alcohols
oxidation of alcohols. Primary alcohols into Aldehydes which can then be further oxidised to CA. Secondry alcohols cna be oxidised into Ketones.
What is the problem with using organic oxidants in aq conditions.
You get oxidation to CA
How can you ensure that primary alcohols are only oxidised to Aldehydes
Remove water and use an organic solvent such as pyridinium chloromate
What do you get when you react an Aldehyde or ketone with water in acidic conditions and what is the mechanism for this.
Hydrate
What do you get if you react an aldehyde or ketone with water under basic conditions and what is the mechanism for this?
Hydrate. The OH- attack the carbonyl and an H+ is removed from water.
What is a hemiacetal?
Where there is an OH and OR group attached to the same carbon
What is an acetal?
Two OR groups attached to the same carbon
What do you get when you react an aldehyde or ketone with an alchol group under acidic conditions
An Hemiacetal or acetal
What do you get if you react a aldehyde or ketone with an alcohol under basic conditions?
Hemiactel as acetals are only made under acidic conditions.
Aldehyde and ketone plus a primary amine gives a?
Imine
What do you get when a aldehyde or ketone reacts with a secondry amine?
Enamine
