Problem 1: Birds and the bees Flashcards
Genotype
Genetic material inherited
Phenotype
Observable characteristics and behaviors that arise from a combination of our genotype and the environment
Chromosome
Chromosomes:
- 23 pairs similar in shape, size, and genetic function (excluding XY).
- 50/50 from both parents.
- The first 22 pairs are autosomes and are homologous (the same) and the 23rd pair is the sex chromosome (XY)
DNA
Double helix molecule connected by nucleotide
- Adenine
- Thymine
- Cytosine
- Guanine
A and T bind together, and C and G too.
Homozygous vs Heterozygous
Homozygous: equal alleles passed on from both parents.
Heterozygous: alleles differ between parents.
Conception
Fertilization > ovum > uterus > fallopian tube > fertilized by sperm > zygote
Mitosis (cell division)
- From 1 to 2, then 2 to 4, then 4 to 8, etc.
- Chromosomes split > duplication of the chromosomes (23 to 46) > they move to opposite sides > division of the cell (identical sets)
Meiosis (cell division)
- Only for sex chromosomes (germ cells)
- They produce gametes
- Duplication of the 23 chromosomes (46) > crossing-over > new unique hereditary combination
- Independent assortment: millions of different combinations.
Monozygotic vs Dyzygotic twins
Monozygotic: 100% identical, one zygote split into two identical cells.
Dygotic: Fraternal, two zygotes from two sperms, 50% identical.
- 22 out of the 23 chromosomes are the same in both females and males.
- The 23rd chromosome defines sex: Males: XY, Females: XX
Single-gene inheritance
Characteristics influenced by one pair (one allele from the mother, one from the father).
- Dominant vs recessive traits.
Co-dominance inheritance
Phenotype of the gene is a compromise between two dominant genes.
Sex-linked inheritance
- Traits located on the X sex chromosomes.
- More common in Males (females counteract the traits by having two X chromosomes unless the allele is dominant in both).
Hereditary disorders: congenital defects
- Effects present at birth but not detectable right away.
Chromosomal abnormalities: Sex chromosomes (Poly X and Poly Y)
- Poly X: 1 in 1000 female births, fertile, low IQ, normal phenotypically
- Poly-Y: 1 in 1000 male births, fertile, low sperm count, normal phenotypically.
Chromosomal abnormalities: sex chromosomes (Klinefelter’s syndrome - males)
- 1 in 1000 births, XXY, feminine traits, phenotypically male, sterile, poor cognitive abilities.
Chromosomal abnormalities: sex chromosomes (Turner’s syndrome XO)
- 1 in 2500 births (females)
- Sterile, normal IQ, one chromosome is missing.