Prion disease

Question 1

Kuru

Answer 1

acquired through cannibalism–> tastes like chicken

Question 2

Variant (vCreutzfeldt-Jakob Disease)

Answer 2

Consumption of meat contaminated with

Bovine Spongiform Encephalopathy

Question 3

Iatrogenic (iCJD)

Answer 3

hormones from cadaver pituitaries, contamination of grafts or surgical instruments, and corneal transplants
(Got to clean the instruments!! serious cleaning)

Question 4

Familial (fCJD)

Answer 4

large number of mutations in PRNP gene with different disease phenotypes

Question 5

Sporadic (sCJD)

Answer 5

etiology is unknown, no known risk factors

Question 6

Inherited Prion diseases: what? where

Answer 6

Rare, inherited mutation in PRNP gene

Resulting in PrPSc

Question 7

PrpSC: what is it

Answer 7

forms beta sheets
converts PrPC into amyloid plaques
(she referred to this as stacking hamburger boxes? why idk)

Question 8

PrPC: what is it

Answer 8

forms alpha helix

PrPC is a ubiquitously expressed glycoprotein involved in cell growth and maintenance

Question 9

Chronic-Wasting Disease (CWD)

Answer 9

Happens in deer and elk

Transmissible Spongiform Encephalopathy (eat the deer)

Question 10

Compare prion to alz

Answer 10

both: amyloid formation, untreatable (you will die)

prion is infectious, alz is not

these are just the big ones she highlighted