Principles of Tox C&D 8

Question 1

LD50

Answer 1

LD50 is the dosage (mg/kg body weight) causing death in 50% of exposed animals

Question 2

Approximate Acute LD50s (mg/kg) of some representative chemical agents:
Ethyl alcohol
Sodium chloride
Ferrous sulfate
Morphine sulfate
Phenobarbital sodium
Picrotoxin
Strychnine sulfate
Nicotine
D-tubocurarine
Hemicholinium-3
Tetrodotoxin
Dioxin (TCDD)
Botulinum toxin

Answer 2

LD50 (mg/kg):

Ethyl alcohol 10,000
Sodium chloride 4000
Ferrous sulfate 1500
Morphine sulfate 900
Phenobarbital sodium 150
Picrotoxin 5
Strychnine sulfate 2
Nicotine 1
D-tubocurarine 0.5
Hemicholinium-3 0.2
Tetrodotoxin 0.10
Dioxin (TCDD) 0.001
Botulinum toxin 0.00001

Question 3

Allometric Scaling of Dose Across Different Species

Answer 3