Principles of Neoplasia

Question 1

Sarcoma

Answer 1

a malignant tumor arising from mesenchymal cells

Question 2

Carcinoma

Answer 2

malignant tumor arising from epithelial cells

Question 3

Lymphoma and leukemia

Answer 3

cancer arising from blood cells and their progenitors

Question 4

Nitrosamines can typically lead to what types of cancer?

Answer 4

gastric cancer

Question 5

Cigarette smoke typically leads to what type of cancer?

Answer 5

multiple malignancies

Question 6

Polycyclic aromatic hydrocarbons typically leads to what type of cancer?

Answer 6

bronchogenic carcinoma

Question 7

Asbestos typically leads to what type of carcinoma?

Answer 7

bronchogenic, mesothelioma

Question 8

Chromium and nickel typically lead to what type of carcinoma?

Answer 8

bronchogenic carcinoma

Question 9

Arsenic exposure typically leads to what type of carcinoma?

Answer 9

sq. cell carcinomas of skin and lung, angiosarcoma of the liver

Question 10

Vinyl chloride typically leads to what type of carcionoma?

Answer 10

angiosarcoma of the liver

Question 11

Aromatic amines and azo dyes typically lead to what type of carcionma?

Answer 11

hepatocellular carcionoma

Question 12

Alkylating agents typically lead to what type of carcinoma?

Answer 12

leukemia, lymphoma, other cancers

Question 13

Benzene exposure typically leads to what type of carcinoma?

Answer 13

leukemia

Question 14

Naphthylamine exposure leads to what type of cancer?

Answer 14

bladder cancer

Question 15

What does Ames test dectect?

Answer 15

any mutagenic effects of potential carcinogens on bacterial cells in culture

Question 16

What is xeroderma pigmentosum?

Answer 16

AR disorder which is an inherited defect in DNA repair in which the pyrimidine dimers formed with UVB sunlight cannot be repaired; this defect predisposes to skin cancer

Question 17

Name an RNA oncogenic virus.

Answer 17

Human T-cell leukemia virus (HTLV-1 causes adult T-cell leukemia/lymphoma

Question 18

Name some DNA oncogenic viruses.

Answer 18

Hep B

EBV

HPV

Kaposi sarcoma-associated herpesvirus (HHV8)

Question 19

Name the tumor, gene product, and MOA of FGF3 and FGF4?

Answer 19

Tumor: cancer of the stomach, breast, bladder and Kaposi sarcoma

Gene product: growth factors, fibroblast growth factors

MOA: overexpression

Question 20

Name the type of tumor, gene products, and MOA of PDGFRA?

Answer 20

Tumor: astrocytoma
Gene product: PDGF
MOA: overexpression

Question 21

Name the tumor, gene products and MOA associated with ERBB1?

Answer 21

Tumor: squamous cell carcinoma of the lung
Gene Product: growth factor receptors, epidermal growth factor receptor
MOA: overexpression

Question 22

Name the tumor, gene products and MOA associated with ERBB2?

Answer 22

Tumor: breast, ovary, lung
Gene product: epidermal growth factor receptor
MOA: amplification

Question 23

Name the tumor, gene products and MOA associated with ERBB3?

Answer 23

Tumor: breast
Gene product: epidermal growth factor
MOA: overexpression

Question 24

Name the tumor, gene product, and MOA associated with RET?

Answer 24

Tumor: MEN 2A & 2B, failial thyroid (medullary) cancer
Gene product: glial neurotrophic factor receptor
MOA: point mutation

Question 25

Name the tumor, gene product, and MOA associated with ABL?

Answer 25

Tumor: CML, ALL Gene product: signal transduction proteins bcr-abl fusion protein with tyrosine kinase activity MOA: translocation t(9;22)

Question 26

Name the tumor, gene product, and MOA associated with KRAS?

Answer 26

Tumor: lung, pancreas, and colon Gene product: GTP binding protein MOA: point mutation

Question 27

Name the tumor, gene product, and MOA associated with MYC?

Answer 27

Tumor: Burkitt lymphoma Gene product: nuclear regulatory protein MOA: translocation t(8:14)

Question 28

What is the tumor, gene product, and MOA associated with MYCL?

Answer 28

tumor: small cell lung carcinoma gene product: nuclear regulatory protein MOA: amplification

Question 29

What is the tumor, gene product, and MOA associated with MYCN?

Answer 29

tumor: neuroblastoma gene product: nuclear regulatory protein MOA: amplification

Question 30

What is the tumor, gene product, and MOA associated with CCND1?

Answer 30

tumor: mantle cell lymphoma gene product: cell cycle regulatory proteins, cyclin D protein MOA: translocation t(11; 14)

Question 31

What is the tumor, gene product, and MOA associated with CDK4?

Answer 31

tumor: melanoma, GBM gene product: cyclin dependent kinase MOA: amplification

Question 32

VHL gene tumor association?

Answer 32

von Hippel-Lindau disease, renal cell carcionoma chromosome 3p25.3

Question 33

WT1 gene tumor association?

Answer 33

Wilms tumor 11p13

Question 34

WT2 gene tumor association?

Answer 34

Wilms tumor 11p.15.5

Question 35

RB1 gene tumor association?

Answer 35

retinoblastoma, osteosarcoma 13q14.2

Question 36

TP53 gene tumor association?

Answer 36

lung, breast, colon, and others 17p13.1

Question 37

BRCA1 gene association?

Answer 37

hereditary breast and ovary cancer 17q21.31

Question 38

BRCA2 gene association?

Answer 38

hereditary breast cancer 13q13.1

Question 39

BRCA2 gene association?

Answer 39

hereditary breast cancer 13q13.1

Question 39

DCC gene association?

Answer 39

colon cancer 18q21.2

Question 39

NF1 gene association?

Answer 39

neurofibromas 17q11.2

Question 39

APC gene association?

Answer 39

adenomatous polyps and colon cancer 5q22.2

Question 40

NF2 gene association?

Answer 40

acoustic neuromas, meningiomas 22q12.2

Question 41

Name some diseases associated with DNA repair?

Answer 41

xeroderma pigmentosum and hereditary nonpolyposis colorectal cancer