Chapter 11: Anemias

Question 1

Aniso?

Answer 1

unequal

Question 2

Poikilo?

Answer 2

various

Question 3

Elliptocyte?

Answer 3

elliptical shaped

Question 4

Spherocytes?

Answer 4

decreased erythrocyte membrane (spherical shaped)

Question 5

Target cells?

Answer 5

result from increased erythrocyte memrbane and can be seen in hemogloinopathies, thalassemia, and liver disease

Question 6

Acanthocytes?

Answer 6

irregular spicules on their surface

Question 7

Echinocytes (burr cells)

Answer 7

similar to acanthocytes but the spicures are smooth and uniform

Question 8

Bite cells are seen in what condition?

Answer 8

G6PD deficiency

Question 9

Basophilic stippling?

Answer 9

results from cytoplasmic remnants of RnA; it may indicate reticulocytosis or lead poisoning

Question 10

Howell Jolly bodies?

Answer 10

are remnants of nuclear chromatin that may occur in severe anemias or patients without spleens

Question 11

Pappenheimer bodies?

Answer 11

composed or iron, and they may be found in peripheral blood following splenectomy

Question 12

Ring sideroblasts?

Answer 12

iron trapped abnormally in mitochondria, forming a ring around nucleus; can be seen in sideroblastic anemia

Question 13

Heinz bodies?

Answer 13

result from denatured hemoglobin; they can be seen in G6PD deficiency

Question 14

What is MCV?

Answer 14

mean corpuscular volume

the avg volume of a red blood cell

Question 15

What is Mean corpuscular hemoglobin?

Answer 15

avg content (mass) of hemoglobin per cell

Question 16

What is Mean corpuscular hemoglobin concentration?

Answer 16

MCHC is the avg. concentration of hemoglobin in a given volume of packed erythrocytes

Question 17

What is Red cell distribution width?

Answer 17

RDW coefficient of variation of red blood cell volume and a measure of anisocytosis

Question 18

What are is an a thalassemia which is a silent carrier state?

Answer 18

one deletion is present and there are 3 alpha genes available

Question 19

What is a-thalassemia trait?

Answer 19

2 alpha delections are present

Question 20

Hemoglobin H disease?

Answer 20

characterized by 3 deletions of a chains with increase HbH (B4 chains) forming Heinz bodies that can be seen wit hcrystal blue stian

Question 21

HbS mutation?

Answer 21

sickle cell anemia when glutamic acid is substituted for valine in B chain

Question 22

Antoher name for B thalassemia major

Answer 22

Cooleys anemia

Question 23

What type of hemoglobin is produced in B thalassemia minor?

Answer 23

HbA2 (2 alpha, 2 delta chains)

Question 24

What is the normal sequence of B12 absorption?

Answer 24

1. dietary B12 binds to salivary haptocorrin
2. haptocorrin B12 complex is broken down by pancreatic proteases
3. Free B12 binds to IF, which is secreted by gastric parietal cells
4. B12-IF complex is absorbed by ileal mucosal epithelial cells
5. B12 is transported in blood bound to transcobalamin

Question 25

List the encapsulated bacteria?

Answer 25

* Streptococcus agalactiae, also known as Group B Streptococcus * Streptococcus pneumoniae, * Haemophilus influenzae, * Neisseria meningitidis, * Escherichia coli, * Salmonella species, * Klebsiella, * Pseudomonas aeruginosa.

Question 26

Be able to reproduce chart on different type of anemia classes.

Question 27

Be able to reproduce chart on ferritin, transferrin (TIBC), serum iron and % sat of transferrin in conditions like iron deficiency anemia, AOCD, and Thalassemia minor.

Question 28

Be able to reproduce chart on ferritin, transferrin (TIBC), serum iron and % sat of transferrin in conditions like iron deficiency anemia, AOCD, and Thalassemia minor.