Chapter 13: Cardiac Pathology Flashcards
CK-MB is elevated by what time in an MI?
4-8 hours
When is CK-MB at its peak after an MI?
18 hours
When does CK-MB return to normal after an MI?
2-3 days
When is Cardiac specific troponin I and T elevated after an MI?
3-6 hours
When does cardiac specific troponin I and T hit its peak after MI?
16 hours
When does cardiac specific troponin I and T return to normal after a MI?
7-10 days
When is LDH elevated by after MI?
24 hours
When does LDH hit its peak after MI?
3-6 days
When do LDH levels return to normal after an MI?
8-14 days
Chart out the gross changes of after an MI timeframes.
Chart out microscopic changes to the heart see after an MI?
Chart the complications in the heart seen after an MI?
Bicuspid valve aortic valve mutation?
NOTCH1
Degenerative calcific aortic valve stenosis.
common valvular abnormality characterized by age-related dystrophic calcification, degeneration and stenosis of the aortic valve
What are the requirements to making a diagnosis of rheumatic fever based on Jones criteria?
2 major or 1 major and 2 minor criteria, plus a preceding group A strep infection
What is Jones criteria?
Used in order to establish diagnosis of rheumatic fever
Acute endocarditis is often caused by what organisms?
staph auerus and high virulence organisms
Subacute endocarditis is usually caused by what organisms?
low virulence organisms such as strep group viridans
Which type of endocarditis, acute or subacute, mostly affects the tricuspid valve.
subacute
Tricuspid valve association in endocarditis is most associated with what?
IV drug abuse
What are some major characteristics to remember about S. Viridans?
alpha-hemolytic
bile resistant
optochin-resistant
What are some signs and symptoms of bacterial endocarditis?
janeway lesions
roth spots
osler nodules
splinter hemorrhage
anemia
fever
What is the Dukes criteria for determining endocarditis?
Major:
blood culture postiive
endocardial involvement
Minor:
fever
immunologic phenomena
vascular phenomena
predisoposition
microbiological evidence
Diagnosis:
2 major criteria;
1 major and 3 minor;
5 minor criteria
What are the HACEK organisms?
the HACEK organisms are a group of fastidious Gram-negative bacteria that are an unusual cause of infective endocarditis, (typically subacute.)
Haemophilus species, Aggregatibacter actinomycetemcomitans, Cardiobacterium hominis, Eikenella corrodens, Kingella kingae
