Principles Of Antimicrobial Use

Question 1

Lymphocytosis (elevated WBC count) is generally associated with

Answer 1

Tuberculosis and viral or fungal infection

Question 2

Abx that can cause kernicterus.

Answer 2

Sulphonamides.

Especially in neonates whom hepatic and liver function are not well developed. Therefore bilirubin excretion is decreased resulting in increased concentration of unconjugated bilirubin

This results from displacement of bilirubin from serum albumin.

Question 3

Hypersensitivity rxn consisting of fever rash abdominal pain and respiratory distress after taking antiretroviral drug abacavir is due to

Answer 3

Presence of human leukocyte antigen allele HLA-B*5701

Question 4

Abx that should be adjusted in patients with severe liver disease

Answer 4

Clindamycin
Erythromycin
Metronidazole
Rifampin

Question 5

Significant accumulation can occur when high liver dysfunction and renal dysfunction are present for these drugs

Answer 5

Cefotaxime
Nafcillin
Piperacillin
Sulfamethoxazole

Question 6

Drugs combination that induce beta lactamases hence result in rapid inactivation of penicillins

Answer 6

Cefoxitin and impenem