Principles and Design of Metabolism

Question 1

Which metabolic transitions are not permitted (2) LO3

Answer 1

Lipid to Carb/Lipid to Protein

Once you go fat you can’t go back

Question 2

What does NADPH do? LO5

Answer 2

Reducing power for biosynthetic rxns

Question 3

What does CoA do? LO5

Answer 3

Universal carrier of acyl groups

Question 4

What are the small energy depleted metabolites of catabolism? LO10

Answer 4

CO2 H20 NH3+

Question 5

What does skeletal muscle use at rest? LO10

Answer 5

Fat

Question 6

What does creatinePO4 do? LO10

Answer 6

fast ATP without metabolizing fuels, quickly exhausted.

Question 7

What fuel does the heart use LO10

Answer 7

fat

Question 8

Fuels made in liver? LO10

Answer 8

Fatty acids, Glucose, Ketones

Question 9

Fuels used by kidneys? LO10

Answer 9

fatty acids, lactate, ketones

Question 10

two organs involved with gluconeogenesis LO10

Answer 10

liver and kidneys. mostly liver except in starvation

Question 11

primary energy source in RBCs LO10

Answer 11

anaerobic glycolysis

Question 12

What fuel source does the small intestine use LO10

Answer 12

glutamine and glutamate

Question 13

energy values of fuels LO8

Answer 13

carb and protein 4, fat 9kcal/g

Question 14

major tissue forms of fuels (4) LO7

Answer 14

G6P Pyruvate AcetylCoA ATP

Question 15

Circulating forms of fuel (6) LO7

Answer 15

glucose lactate amino acids triglycerides fatty acids ketones

Question 16

four metabolites at branch points LO9

Answer 16

G6P Pyruvate Acetyl CoA Glutamate

Question 17

cytosolic pathways (5) LO4

Answer 17

Glycolysis, Pentose PO4, Fatty Acid Nucleotide Protein Synthesis

Question 18

Mitochondrial pathways (5) LO4

Answer 18

TCA, Ox Phos, B oxidation of Fat, Ketogenesis and oxidation

Question 19

cytosolic and mito paths (3) LO4

Answer 19

gluconeogenesis, urea and steroid synthesis

Question 20

smooth er paths (4) LO4

Answer 20

triglycerides, phospho/glycolipid syn, cholesterol, hydroxylation/detox (cytochrome p450)