Principles Flashcards
Which type of antibiotics work on cell wall?
Penicillin (flucloxacillin, co-amoxiclav and amoxicillin)
Cephalosporin (ceftriaxone)
Glycopeptides (vancomycin)
Are antibiotics that work on cell wall bactericidal (kill) or bacteriostatic (inhibit growth)?
All bactericidal
Which antibiotics inhibit protein synthesis?
Macrolides (erythromycin, clarithromycin, azithromycin)
Tetracyclines (doxycycline)
Aminoglycosides (gentamicin)
Are antibiotics that work on cell wall bactericidal (kill) or bacteriostatic (inhibit growth)?
Macrolides and tetracyclines are bacteriostatic
Aminoglycosides are bactericidal
Which antibiotics work on bacterial DNA?
Metronidazole
Trimethoprim
Fluroquinolones (ciprofloxacin, levofloxacin)
Are antibiotics that work on bacterial DNA bactericidal (kill) or bacteriostatic (inhibit growth)?
Metronidazole and quinolones are bactericidal
Trimethoprim is bacteriostatic
Which antibiotics should you avoid in pregnancy?
Trimethoprim and metronidazole in first 3 months
Avoid gentamicin, tetracyclines and quinolones completely
What are the 4 Cs which should be avoided to prevent C diff infection?
Clindamycin
Cephalosporins
Co-amoxiclav
Ciprofloxacin
In general, what is used for Gram +ve cover?
Flucloxacillin IV for staph (vancomycin if allergic)
Oral switch = doxycycline
In general, what is used for Gram -ve coliforms and pseudomonas?
Gentamicin / aztreonam IV if severe
Oral co-trimoxazole / doxycycline if suitable for oral treatment
What is used for treatment of anaerobes?
Metronidazole
What is used for treatment of staph epidermis?
Vancomycin
What is used for treatment of MRSA?
Vancomycin
