Primer 9

Question 1

Structures Derived from Branchial Pouches 1-4

Answer 1

1: mastoid air cells, middle ear cavity, eustacian tubes
2: lining of palatine tonsils
3: Thymus, Inferior* parathyroid
4: Superior parathyroid

Question 2

Contents of cavernous sinus:

Answer 2

CN III, IV, V1, V2, VI

Internal carotid artery

Question 3

4 key clinical features of osteogenesis imperfecta:

Answer 3

1. Blue sclera
2. Brittle bones–> many fractures
3. Dental irregularities
4. Hearing loss

Question 4

Tamsulosin: MOA and clinical use?

Answer 4

Selective a-1AD blocker (localized to prostate)

TX: BPH only; has less effect on BP!

Question 5

List 3 selective a-1 blocker drugs and their effects + clinical uses:

Answer 5

DECREASE TPR (BP), Bladder sphincter tone:

1. Parasosin
2. Doxasosin
3. Terasosin

TX: HTN, BPH

Question 6

3 ADRS of a-1 antagonists:

Answer 6

1. Postural HypoTN
2. Reflex tachy
3. Rebound HTN with rapid w/drawal

Question 7

2 Nonspecific a antagonists, their clinical use

Answer 7

1. Phenoxybenzamine- irreversible binding to receptor–Dx. pheochromocytoma
2. Phentolamine

Question 8

3 Nonspecific b-blockers + Tx:

Answer 8

1. Propranolol: anxiety, HTN, ~CHF
2. Timilol- glaucoma
3. Nadolol- Glaucoma

Question 9

2 Selective b-1 blockers:

Answer 9

Metorolol, Atenolol

Question 10

B-Blockers that act as non-specific partial agonists (2):

Answer 10

1. Acebutolol

1. Pindolol

Question 11

2 mixed a-1, b-1 blockers:

Answer 11

Carvedelol, Labetalol

Question 12

Can b-blockers cause erectile dysfunction?

Answer 12

NO: remember “POINT AND SHOOT!”– doesn’t make sense!

Question 13

4 ADRs associated with B-Blockers:

Answer 13

1. Bronchoconstriction
2. Rebound Tacky, HTN, Arrythmia
3. Decrease blood glucose + inhibit sympathetic response to hypoglycemia
4. Bradycardia, AV block

Question 14

4 CI’s for B-blocker use:

Answer 14

1. Asthma, COPD
2. DM on meds
3. Cocaine OD (unbalanced a-1 activation!)
4. CHF patients in acute attack

Question 15

6 general clinical uses for b-blockers:

Answer 15

1. HTN
2. CHF
3. Supraventricuar Tachy
4. Angina
5. MI
6. Glaucoma

Question 16

Medical treatment and diagnosis of pheo:

Answer 16

a-agonists!

Question 17

Drug used to treat BPH and its moa?

Answer 17

Tamsulosin; selective a-1AD block!