Primary Progressive Aphasia

Question 1

PPA Variants

Answer 1

1. Progressive Non-Fluent Aphasia (PNFA)
2. Semantic Dementia (SD)
3. Logopenic Progressive Aphasia (LPA)

Question 2

Progressive Non-Fluent Aphasia (PNFA)

• Most Common Deficits

Answer 2

• agrammatic output

• motor speech impairments
(apraxia of speech, dysarthria)

• impaired comprehension of
complex sentences

• anomia (particularly for verbs)

Question 3

Progressive Non-Fluent Aphasia (PNFA)

• Preserved Behaviors

Answer 3

• semantic processing

• comprehension for
single-words and simple
sentences

• auditory-verbal shortterm
memory (AVSTM)

Question 4

Progressive Non-Fluent Aphasia (PNFA)

• Neuroanatomy

Answer 4

Predominant left posterior frontoinsular

atrophy

Question 5

Progressive Non-Fluent Aphasia (PNFA)

• Pathology

Answer 5

• Corticobasa degeneration

* Progressive supranuclear palsy

Question 6

Semantic Dementia

• Most Common Deficits

Answer 6

• severe anomia

• poor single-word comprehension
(particularly for low-frequency
items)

• multi-modal semantic memory
impairment

• surface dyslexia

Question 7

Semantic Dementia

• Preserved Behaviors

Answer 7

• motor speech

• expressive syntax
(fluency)

• sentence comprehension

Question 8

Semantic Dementia

• Neuroanatomy

Answer 8

Predominant left anterior temporal lobe atrophy

Question 9

Semantic Dementia

• Pathology

Answer 9

Frontotemporal dementia related

pathology

Question 10

Logopenic Progressive Aphasia (LPA)

• Most common deficits

Answer 10

• anomia

• poor phase and sentence repetition
due to impaired AVSTM

• phonological errors in
spontaneous speech and naming

Question 11

Logopenic Progressive Aphasia (LPA)

• Preserved Behaviors

Answer 11

• motor speech
• semantic processing

• single-word
comprehension

Question 12

Logopenic Progressive Aphasia (LPA)

• Neuroanatomy

Answer 12

Predominant left posterior perisylvian or

parietal atrophy

Question 13

Logopenic Progressive Aphasia (LPA)

• Pathology

Answer 13

Alzheimer’s disease