Primary biliary cirrhosis Flashcards
1
Q
What is primary biliary cirrhosis?
This condition is associated with which antibodies?
A
Autoimmune destruction of the bile ducts in the liver
Anti-mitochondrial antibodies
2
Q
Describe the clinical features of primary biliary cirrhosis
A
Features of cholestasis:
- Pruritus
- Jaundice
- Pale stools and dark urine
3
Q
What will the LFTs show in a patient with primary biliary cirrhosis?
A
“Cholestatic”/obstructive picture:
- Alk phos high
- Bilirubin high
4
Q
Which investigation is used to diagnose and stage PBC?
A
Liver biopsy
5
Q
Describe the medical management of PBC
A
Symptomatic:
- Cholestyramine (relieves itching)
Disease-modifying:
- Ursodeoxycholic acid
