Primary amenorrhoea Flashcards
1
Q
Central causes of Primary amenorrhoea
A
functional hypothalamic hypogonadism Kallman's constituitional delay in puberty CNS disorder Prolactinoma Panhypituitarism
2
Q
Peripheral causes of Primary amenorrhoea
A
gonadal failure
arrested puberty
anatomical
3
Q
Causes of Gonadal failure
A
Turners 45XO
Fragile X syndrome
Swyer’s syndrome 46XY
POF - infections, autoimmune, chemo, radio, galactosaemia
4
Q
Causes of arrested puberty
A
CAIS
Premature ovarian insufficiency
5
Q
Causes of anatomical primary amenorrhoea
A
MKRH imperforate hymen vaginal septum vaginal agenesis cervical agenesis
6
Q
Turner’s syndrome management
A
Renal scan Risk of HTN Hearing loss ECHO - left-sided obstructive cardiac abnormalities (coarctation) TFTs-primary hypothyroidism vision- strabismus T2DM risk IBD risk Bone health - GH therapy Pubertal induction - oestrogen Psychosocial issues
7
Q
Management of gonadal dysgenesis
A
MDT Gonadectomy Pubertal induction Bone health Fertility Counselling
