Prevention/Anticipatory Guidance Flashcards
Definition of anticipatory guidance
To provide developmentally relevant information about a child’s health to help prepare parents for milestones in the future
Definition of dental caries
Chemical dissolution of tooth surface caused by metabolic events in the biofilm covering the affected area
Contributing factors to caries
Oral hygiene Diet Microbiology Fluoride Genetics (immune, enamel, saliva) Environmental factors
Keyes Triad
Host and teeth
Microflora
Substrate (diet)
Very simplistic approach
Koch’s Postulates
Describes requirements for a microorganisms to be considered in an etiologic agent for disease
Found in all cases of disease
Organism should be grown on artificial media for several subcultures
Pure subculture should produce disease in susceptible animal
Not able to be done in caries
-many confounders (behavior, education, SES, genetics, etc.)
Specific Plaque Hypothesis
Only certain species of bacteria are involved in caries process
Nonspecific Plaque Hypothesis
All plaque/bacteria are pathogenic
Ecological Plaque Hypothesis
Shifts in pH of biofilm cause a shift toward cariogenic bacteria (S mutans) in the balance of resident oral flora, resulting in dsease
Extended Caries Ecological Hypothesis
Dental plaque as a dynamic microbial ecosystem in which non-mutans bacteria are key players for maintaining dynamic stability
Low pH environments can stimulate non-mutans bacteria to be more acidogenic
Variety of bacteria that are acid-producing, not just S mutans
Given the right environment, even the good bacteria can cause demineralization and destruction of tooth surface
Composition of enamel
95% hydroxyapatite
- 5% water
- 5% organic matrix
Calcium phosphate crystals make up 99% of dry weight
Active vs inactive carious lesion
Active lesions: white, opaque, rough
Inactive lesions: smooth, hard
White Spot Lesion
Intact surface zone: 20-50um
Body of lesion - pore volume > 5%
Dark zone - pore volume 2-5%
Translucent zone - advancing front of lesion
Dentin reaction to caries
Vital tissue that reacts to external insults
Most common reaction to caries progression is tubular sclerosis and occlusion of dentin
Pulp-dentin reactions
Histologically early signs of tubular sclerosis can be seen before the enamel lesion reaches the DEJ
Dentin demineralization does not extend laterally beyond contact area with enamel lesion
Reactionary dentin may form before dentin is invaded by bacteria
Biofilm
Necessary but not sufficient to cause disease
Microbial biofilm on teeth is prerequisite of caries lesions
Primary route of transmission of caries
Saliva
Vertical transmission from mother
Early colonizers of bacteria
S. Mitis
S. Salivarius
S. Oralis
Prior to tooth eruption, these bacteria are transient, usually on gingival tissues
Acquired pellicle formation
Acellular, proteinaceous film that forms on teeth within minutes after cleaning
Composed of salivary glycoproteins, phosphoproteins, lipids and components from gingival crevicular fluid
1 micron thick
Critical role in bacterial colonization
Facilitates remineralization by maintaining calcium and phosphate
Microbial succession
Early bacteria create environment either favorable to others or unfavorable to themselves
Gradual replacement with other species who are better suited to modified environment
Microbial hemostasis is a state of equilibrium between microflora and local environment
Disruption can result in disease
Characteristics of cariogenic bacteria
Rapid transport and conversion of sugars to acid
Ability to maintain metabolism under extreme conditions like low pH
Production of extracellular polysaccharides such as glucans that shift to acidic
Acid producing cocci and rods
SECC bacteria
More anaerobic cultures found
S sanguinis generates alkali from arginine and decreases cariogenicity of acidogenic bacteria
Window of Infectivity
Between 19-31 months of age
Window appears to close after all primary teeth erupt
Once stable plaque or biofilm covers tooth surface, MS is less likely to be established
2nd window of infectivity at 6 years when 1st molars erupt
Transmission of caries
Vertical: parent to child (most often from mother)
Horizontal: spouses
Factors affecting acquisition of MS
Erupted teeth
Presence of hypoplasia
Diet high in fermentable carbohydrates
Antibiotic intake (?) - conflicting results
Stephan Curve
Curve that shows the pH drop after sucrose intake
Shows time below 5.5 pH where demin is occurring
Takes up to 30 minutes to buffer back to neutral
Why frequency is important
Critical pH
Varies depending on total calcium and phosphate concentration in saliva
Average 5.5 for hydroxyapatite
Average 4.5 for fluorapatite
Low concentrations of calcium and phosphate can increase the critical pH as high as 7 in some people
Remineralization
Saliva acts as source for calcium and phosphate that helps in maintaining supersaturation with respect to tooth minerals
When saliva is stimulated, rapid rise in pH occurs, calcium phosphate and glycoprotein called salivary precipitin is formed - complex readily incorporated into dental plaque
Fluorapatite
Fluorapatite has higher pH for dissolution
Displacement of hydroxide with fluoride removes a weakness of hydroxyapatite to lactic acid
Overview of Fluoride
Fluorine = most electronegative element
Fluoride is widespread in nature (water, milk, vegetables)
NaF= sodium fluoride SnF2 = stannous fluodie Na2PFO3 = sodium monofluorophosphate (MFP)
Does fluoride cross the placenta?
Most does not cross
No evidence that prenatal fluoride supplements taken by women during pregnancy are effective in preventing dental caries in offspring
Fluorosis and infant formula
Clinicians should consider potential fluoride exposure to infants when fluoridated water is used to reconstitute infant formula
1ppm = 1mg/L
Ex: if baby drinks 2.5oz/lb/day, 10lb baby drinks 25oz or 3 cups per day
-if powdered reconstituted with fluoridated water, 0.64-1.07ppm = 0.72mg F
Mechanism of Fluoride
Frequent exposure to topical fluoride is more effective in caries prevention than fluoride that is incorporated into enamel through systemic exposure during tooth development
Main mechanism = enhance remineralization and inhibit demineralization (topical)
Systemic effect (increase crystallinity of enamel) is minor
Antimicrobial effect is minor
Fluoride in toothpaste
Sodium fluoride dentifrice offers greater cariostatic activity than MFP
Increased fluoride concentration leads to increased cariostatic activity
Fluorosis
Permanent, intrinsic stain caused by excessive fluoride during tooth development
Usually white, but can be brown/orange
Severe cases damage tooth enamel
Directly related to total fluoride ingested during tooth development
Permanent maxillary molars most susceptible during first 3 years of life
Can affect both dentitions
Community water fluoridation
0.7ppm
Used to be 0.7-1.2ppm but changed in 2015
Goal is to maintain anti-caries effect but minimize risk of fluorosis
Amount of fluoride in regular toothpaste
1000ppm
Fluoride mouthrinse
Provides moderate dose (226mg/L) fluoride topically on daily basis for those using it
Effective and available OTC
Not for young children
Professionally applied fluoride gels
High dose (12,400pmp) of fluoride 1-2 times per year
Contraindicated in younger children due to ingestion control concerns
Frequent use is impractical and expensive
Professionally applied fluoride varnish
High dose (22,500ppm) of fluoride several times per year
Effective under providers’ control and locally retained for several hours
Small amount used, less ingestion
Dietary fluoride supplements
Provides moderate dose (0.25-1mg per tab) on daily basis
Designed to take place of fluoridated water
Indicated if child not living in fluoridated community