Preterm, prenatal exposures, FASD

Question 1

second hand smoke in 18 months (urine cotinine)
what developmental area affected

Answer 1

may reduce gross motor, fine motor and language development (Wei et al 2021)

Question 2

Name the FASD treatment categories

Answer 2

4 different treatment domains

Question 3

2 neuroimaging findings in child with CMV

Answer 3

peri-ventricular or ventricular calcifications
brain atrophy
ventriculomegaly
structural anomali

Question 4

Congenital Zika features - 3 clinical or imaging findings

Answer 4

Cerebral atrophy, hypoplasia or calcification
Microcephaly
Marked spasticity and hypertonia
club foot or arthrogryposis
Chorioretinal atrophy

Question 5

2 anatomical aspects of a childs anatomy that make them more susceptible to brain injury

Answer 5

relative macrocephaly
weak neck muscles
Elastic blood vessels
Incomplete myelination

Question 5

3 sentinal facial features of FASD

Answer 5

Question 6

6 difficulties in FASD to advise a teacher

Answer 6

Attention
Memory
Executive function
Communication challenges
Emotional dysregulation
Social challenges
Adaptive skills

Question 7

3 syndrome that have dysmorphic features similar to FAS

Answer 7

22q11 microdeletion
Williams
Noonan
Cornelia de Lange syndrome
Fetal PKU
fetal VPA

Question 8

Classroom strategies for FASD
Name 5 specific strategies

Answer 8

Question 9

Area of relative strengths from CANFASD

Answer 9

Auditory memory
Non-verbal abilities
Friendly
Determined and hard working

Question 10

10 neurodevelopmental domains of FASD

Answer 10

Attention
Executive functioning
Memory
Language
Motor
Social/Adaptive
Academic performance
Cognitive
Affect regulation
Neuroanatomy/Neurophysiology

CLEAN A,S MAMA

Question 11

What 6 neuropsyc domains with psych and associated tests in FASD

Answer 11

Intellectual Disability - WISC-V or WPPSI IV

Motor Impairment - Beery VMI or BOT 2

Attention impairment - BASC -3 or impairments in processing speed and working memory on WISC, Conners, SNAP-IV

EF impairment - BRIEF2

Language impairment - core language - CELF P3/CELF-5; CELF metalinguistics

Adaptive impairments - ABAS-3 or Vineland 3

Academic impairment - WIAT III or KTEA-3a

Question 12

3 major signs of FASD

Answer 12

facial features
prenatal alcohol exposure
functional impairments in at least 3 brain based domains

Question 13

3 diagnosis (DSM) that late term infant is more at risk for (37 weeks)

Answer 13

ADHD
DCD
Specific learning disorder

Question 14

4 risk factors in neonatal period for school difficulties in ex-preterm

Answer 14

LBW
extreme preterm
HIE
IVH
hypoglycemia
neonatal infection
ROP

Question 15

name 5 team members for an ex-preterm wtih CP

Answer 15

Neuromotor team
Neurology
Orthopedics
Ophthalmology
Audiologist
Occupational therapy
Physiotherapy
Paediatrician
Social worker

Question 16

follow up topics in ex 26 weeker to review before starting school

Answer 16

Question 17

1 test to order in wrestles leg syndrome

Answer 17

ferritin

Question 18

6 neonatal effects of SSRI in utero

Answer 18

Poor muscle tone
Tremors/jitteriness
Irritability
Seizures
Feeding difficulties
Sleep disturbances
Hypoglycemia
Respiratory distress

PNAS, also referred to as neonatal withdrawal syndrome and serotonin discontinuation syndrome, has been described in up to 30% of newborns exposed to maternal SSRI or SNRI use in utero, particularly during the third trimester

NOT at risk for higher internalizing or anxious behaviors, ADHD or ASD

Maternal mood including depressed mood accounts for most of the child behavioral outcomes.

Question 19

Agenesis of the corpus callosum
3 developmental/behavioral findings

Answer 19

Impaired attention (ADHD)
ID - delayed cognitive processing
SLD
Impaired pragmatic language skills
Impaired core language
Impaired hand eye coordination
Vision problems

Highly highly variable
Paper (2023) John Willie and Sons

Question 20

school difficulty that suggest brain abnormality (?absent corpus callosum)

Answer 20

Attention /ADHD
specific learning in math
language
cognition

Question 21

Name the 9 areas of impairment outside of neuroanatomy/neurophsyiology evaluated in FASD

Answer 21

Question 22

name 5 clinical features of FASD outside of domains, PAE, and sentinal facial features

Answer 22

Microcephaly
Oral facial cleft
Clinodactyly
Short 5th digits
CHD (ASD, VSD, ToF, great vessel anomalies)
Kidney anomalies
Radioulnar synostosis
Ear malformations
Single palmar crease
Growth restriction

Question 23

Physical features and imaging findings of Zika (5)

Answer 23

Microcephaly
Ventriculomegaly
Parenchymal or cerebellar calcifications
Atrophic cerebral cortex, cerebellum, brainstem
Corpus callosum anomaly
Hydrocephalus.
Cardiomegaly
Diaphragmatic paralysis (seen on CXR)