Prescribing for Hypertension Flashcards
Used to treat isolated systolic hypertension in the elderly
A. Ramipril
B. Amlodipine
C. Metoprolol
D. Hydrochlorothiazide
B
- A 45 y.o. hypertensive patient has unsuccessfully tried lifestyle modification to control his bp.
He is now to be given several drugs to maintain bp to normal levels. As the physician in charge,
you are concerned by drug interaction caused by changes in drug metabolism. You would likely
surmise that products of drug metabolism are:
A. More likely to produce adverse effects
B. More likely to be reabsorbed by kidney tubules:
C. More likely to have a half-life of 2
D. Less lipid soluble than the parent compound.
B
Lippincott Pharmacology 5th Edition Chapter 1 V: “The kidneys cannot efficiently eliminate
lipophilic drugs that readily cross cell membranes and are reabsorbed in the DCT. Therefore
lipid-soluble agents must first be metabolized into more polar (hydrophilic) substances in the
liver using 2 general sets of rxns: Phase I and Phase II
Which of the ff should not be given to pregnant hypertensive patients:
A. Enalapril
B. Methyldopa
C. Hydralazine
D. Nifedipine
A
ACE Inhibitors and ARBs are contraindicated for chronic hypertension in the setting of
pregnancy because:
A. Oligohydramnios
B. Growth retardation
C. Neonatal anuric renal failure and renal agenesis
D. All of the above
D
Results show protein dipstick shows +2 for a patient with platelet count 130,000, normal
liver enzymes and normal chest x-ray. How would you manage this patient assuming it is also a
case of pregnancy?
A. Maintain her bp >150 systolic
B. Start her on methyldopa
C. Complete bedrest
B
