Drug Interactions Flashcards
Strategies for preventing ADRs and drug interaction
A. Use the newest drugs on the market
B. Regularly review your patients medications especially over-the-counter drugs and food
supplements
C. Be careful especially with drugs that have wide therapeutic margins
D. AOTA
B
Pharmacokinetic drug interactions involve the following
A. Drug A decreases the absorption of drug B
B. Drug A displaces drug B from protein binding
C. Drug A increases clearance of drug B
D. AOTA
D
9) The precipitant drug has the following property
A. Low toxic/therapeutic ratio
B. Drug that is affected
C. Affects metabolizing enzyme thus affecting clearance
D. Low protein binding
C
A and B refer to the object drug. Precipitant drugs have high protein bindihttp://time.com/3728490/workout-you-can-do-anywhere/ng
Direct pharmacodynamic drug interaction includes the following
A. Drug-excipient
B. Drug-container
C. Drug-receptor
D. IV incompatibilities
C
A patient taking metoprolol experiences bradycardia. Which enzyme is affected?
A. CYP 2D6
B. CYP 3A4
C. CYP 2C19
D. CYP 1A2
A
Warfaring is metabolized by CYP3A and then ketoconazole (a CYP3A inhibitor) was given.
What is likely to happen?
A. Increased risk of bleeding
B. Decreased risk of bleeding
C. No effect
A
Which of the following is NOT a preventable cause of ADR?
A. Inappropriate polypharmacy
B. Failure of medical personnel to attribute new symptoms to drug therapy
C. Attending physicians not talking and discussing with each other regarding the case
D. Using newly approved but potentially life-saving drugs
D
Unique adverse effects of meds in children
A. Phenobarbital – hyperactivity
B. Benzodiazepine – less respiratory depression
C. Isoniazid – hepatotoxic so LFTs must be done
D. Metoclopramide – less likely to cause dystonic movements
A
An immunocompromised patient was treated for pneumonia with parenteral penicillin. Within
minutes, he developed sudden bronchoconstriction, laryngeal edema and hypotension. The
drug reaction caused by penicillin was mediated by:
C. Mediated by IgE
D. Type II reaction
Type I hypersensitivity reaction, hence IgE.
C
Pharmaceutical drug interactions include the ff:
A. IV drug incompatibilities
B. Drug-container interaction
C. Drug-excipient interaction
D. All of the above.
D
Strategy/ies to avoid adverse drug interaction includes the following:
B. Be particularly careful when you prescribe to children, pregnant patients, elderly etc.
C. Review your patient regularly for all the drugs used.
D. All of the above
D
