Prenatal Diagnosis - Hershkovitz Flashcards
1
Q
What are biochemical markers for screening Downs Syndrome?
A
Triple test:
Increased hCG
Decreased AFP
E3
Gives 65% accuracy
Combined test:
Free beta hCG
Pregnancy Associated Plasma Protein A (PAPPA)
Nuchal Translucency >3cm (65% by itself)
Gives 85% accuracy
Integrated test
Inhibin
Decreased AFP
at 16-18 weeks
Gives 95% accuracy
Amnio performed when triple test above 1/370 or >35 and >1/270
