Prenatal Flashcards by Andrew McCarty

Q

AFP affected by

A

race, wt, DM(lower)

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Q

Quad screen when

A

16-17 weeks (15-18 up to 20)

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Q

A-thal is in what pops

A

SE Asia, China

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Q

B thal in what pops

A

Africa, SEAsia

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Q

SMA cyto location

A

5q11`

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Q

when is safe from teratogens

A

6-9days

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Q

Penicillamine tet effect

A

cutis laxa

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Q

rubella, highest risk time

A

1-3 mo`

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Q

syphillias tet effect

A

W-teeth, plaques, skin, CNS

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Q

carbazepine)anti convulsant

A

ONTDs

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Q

DM tet effect

A

CHD, NTD, limb, holopros

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Q

3 IMPORTANT ASSESS OF TERATOGEN

A

TIMING, DOSE, INDICATION

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Q

CUTOFF FOR HIGH RISK

A

1/270

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Q

PaPPA performed when?

A

10-12wks

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Q

1st tri screen when

A

11-14wks

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Q

integrated resulted when

A

1st plus 2nd, given in 2nd

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Q

Sequential resulted when

A

resulted 1st and 2nd

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Q

CMV

A

IUGR, eye, ear brain

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Q

HPV

A

slpapped cheek, arthritis

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Q

Rubela risk when

A

1-3 month

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Q

syphillias

A

w teeth plaques, CNS

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Q

androgens

A

ambiguosu genetalia in girls

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Q

hydantoin

A

NAILS, dd,GROWTH delay

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Q

DM

A

CHD NTD limb holopro

safe period in preg

6-9days

A thal screened in

SE asia, S china

B thal screened in

Africa, SE asia

NDJ risk aat 20

1500

NDJ risk at 35

1/400

NDJ risk @ 40

1/100

% DS abort

75%

Kleinfelter primarily what error

M1 male

TUrner risk

1/1500

RObertsonian risk

1/1000

reciprocal translocation risk

1/500

kleinfelter errors?

Male M1 50%

Recip trans risk

20%RR if prev child 4% if SABs x n 8% if dx prenatally

MSAFP detects ONTDS %

90

MSAFP test when

16-18 optomal , 15-20 sub opt

first tri screen done?

9-13.6

1st tri detection

90%

Nt done

11-13.6

2nd tri screen when

15-20

2nd tri detection

80%

stepwise given

1st and 2nd serum or dx ifhigh

before 20 wks

offer ONTD

if before 14

offer 1st tri

if done CVS 1st tri

still offer NTD

NT above 3.5

prompt US echo

DS risk SDR

none inc

rob13q21q risk

15% mom, .5dad for 21 also 13

rob 14q21q risk

15 mom, 1% dadalso UPD 14

amnio risk

1/300

cvs risk

1/100-200

integrated # when

2 visits result in second 96%

stepwise

stratefied 2 visits

NIPT tested when

10.-21

US done when

10.4-13.6 +