Premalignant And Malignant Disease Of The Cervix Flashcards
What is cervical intraepithelial Neoplasia
It is a spectrum of intraepithelial changes which begins from mild atypia and progresses through more marked stages of intraepithelial abnormalities to carcinoma in situ and usually to squamous cell carcinoma
The ectocervix is lined by
Stratified squamous epithelium
The endocervix is lined by
Columnar epithelium
The junction of the two types of epithelium is the
Squamo-columnar junction
What is a nabothian cyst and what may cause it
Mucus filled cysts on the surface of cervix.
They are most often caused when stratified squamous epithelium of the ectocervix grows over the simple columnar epithelium of the endocervix.
HPV is a large encapsulated DNA virus and belongs to the family
Papovaviridae
HPV can be divided into two sero-types
Low risk
High risk
HPV Types in low risk
6, 11, 26, 42, 43, 44
HPV types in high risk
16, 18, 31, 33, 35
What are the risk factors for the pre malignant and malignant lesions of the cervix
Early coitarche
Persistent infection with high risk oncogenic HPV
Multiple sexual partners
Male partner with multiple sexual partners
Use of oral contraceptives
Smoking
Low socioeconomic status
Diagnosis for CIN is made after biopsy is taken during
Colposcopy
Features observed on colposcopy
Abnormal vascular pattern
Acetowhite reaction on application of dilute acetic acid
Iodo-negative on application of Lugol’s Iodine
What are the screening tests for the pre malignant lesions of the cervix
HPV DNA screening
Cytology(Conventional Pap Smear/liquid based cytology)
Visual Inspection with acetic acid
Visual Inspection with Lugol’s Iodine
Pap smears are reported using the
Bethesda Classification
Visual inspection with Lugol’s Iodine is also known as
Schiller’s test
