Infertility Flashcards

1
Q

Define infertility

A

Inability of a couple to achieve conception after one year of regular, unprotected sexual intercourse

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2
Q

Above 30 years, Females may be investigated after how many months of adequate unprotected sexual intercourse

A

6 months

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3
Q

What is adequate intercourse?

A

Minimum of 3 sexual episodes in a week each 1 to 2 days apart

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4
Q

It is estimated that how many percent of couples have difficulty

A

20%

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5
Q

Infertility can be classified into

A

Primary infertility
Secondary infertility

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6
Q

The aetiology of infertility may be grouped into

A

Male factors
Female factors

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7
Q

Female factor infertility can be divided into

A

Hormonal factors
Ovulation factor
Tubal factors
Uterine factors
Cervical factors

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8
Q

What conditions may alter the pulsatile release of GnRH from the hypothalamus

A

Stress, emotional disturbances, weight changes, thyroid dysfunction and medication

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9
Q

What can lead to tubal blockage

A

Pelvic infections from PID,

Appendicitis and pelvic surgeries can alter motility or cause peritoneal adhesions

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10
Q

What can affect the implantation of fertilized egg into the endometrium(Uterine factors)

A

Factors causing endometritis (Infection, IUCD)
Submucous fibroids

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11
Q

Cervical factors of infertility may be due to

A

Conditions that increase or decrease cervical mucus

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12
Q

What are factors that may decrease cervical mucus

A

Increasing Age
Medications(Anti-histamine)
Dehydration
Smoking
Stress

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13
Q

What are factors that increase cervical mucus

A

Sexual arousal
Pregnancy
Infection
Medication (Clomiphene)
PCOS & thyroid hormone imbalance

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14
Q

What are factors that increase cervical mucus

A

Sexual arousal
Pregnancy
Infection
Medication (Clomiphene)
PCOS & thyroid hormone imbalance

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15
Q

Male factor infertility can be attributed to two things and they are

A

Conditions that affect erection (ED)
Conditions that affect spermatogenesis

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16
Q

Conditions that affect spermatogenesis can be divided into and what may cause them

A

Congenital conditions: Klinefelter’s Syndrome, Undescended testes

Acquired: Mumps Orchitis, Inguinal surgeries, Irradiation, Chemotherapy and exposure to toxins(pesticides)

17
Q

Important info that may be ascertained from history in the management of infertility in the Man

A

Prev history of STD
Mumps Orchitis
Inguinal Surgeries
Irradiation
Testicular Cancers
Chemotherapy
Leprosy
Hydrocele

18
Q

Important info that may be ascertained from history in the management of infertility in The Woman

A

Previous history of PID
Galactorrhoea
Hirsuitism
Excessive acne
Amenorrhoea
Post abortion sepsis
Previous TB
Laparotomy for peritonitis/appendicitis
Pelvic surgeries
Delayed puberty

19
Q

The most important investigation done to identify cause of infertility in male is

A

Semen analysis and culture

20
Q

What is the normal sperm conc in semen analysis

A

15,000,000 or more per ml

21
Q

What is the normal total sperm count is

A

> 39 million per ejaculate

22
Q

What is the normal volume of semen

A

1.5ml

23
Q

Important investigations done to identify cause of infertility in females include

A

Abdomino-pelvic USS
Hysterosalpingogram (HSG)
Hormone profile; LH, FSH, TSH, Prolactin, Eatrogen, Androgens and Progesterone
ECS mcs
Laparoscopy and dye test
Hysterocontrast sonography

24
Q

Medical treatment of infertility

A

Based on cause
Ovulatory factors: Ovulation Induction Agents (Clomiphene, Letrozole), GnRH analogoues
Hyperprolactinaemia: Bromocriptine, Carbegoline

25
Q

Surgical treatment of Infertility

A

Tubal canulation and tuboplasty, IVF-ET