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premalignant Flashcards

1
Q

MC site for basal nodular and superficial?

A

nodular: nose
superficial: trunk

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2
Q

what is the MOA for 5 fluorouracil treatment?

A

thymidylate synthatse inhibitor: the necleoside required for DNA replication

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3
Q

what is the most imporant risk factor for basal cell carcinoma?

A

inability to tan

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4
Q

risk factors for SCC?

A

chemo, UVA/UVB, HPV, thermal/radiation burns, chronic irritation, arsenic

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5
Q

how long is 5FU treatment and how long may irriation last?

A

2-4 week treatment, irritation 2-4 weeks

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6
Q
A

scc

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7
Q
A

bowen’s disease

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8
Q
A

basal cell carcinoma

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9
Q

meds that are used w/ 5 FU treatment?

A

OTC HC 1% or Rx desonide cream

aquaphor/pertrolatum

oral analgesics

prescribe in winter or fall

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10
Q

what is the treatment for bowen’s?

A

small: electrodessication and curettage, cryo, excision
large: excision, 5-FU

q 6 month follow up

recurrence is common

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11
Q

what is MC invasive skin CA?

A

basal cell carcinoma

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12
Q

what cuases actinic keratosis, where is it confined to, what is it a precursor to, what is its treatment?

A

chronic uvb, confined to epidermis, scc,

photoprotection, complete skin exam, liquid nitrogen if few, 5-f/u if multiple

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13
Q
A

actinic keratosis

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14
Q

what is actinic keratosis on the ear and what is the treatment?

A

chondrodermatitis nodularis helicis

excies it speciall pillow for sleeping

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15
Q

what is actinic ketatosis on the lip called?

A

actinic chelitits

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16
Q

what is bowen’s disease associtated w/?

A

erythroplasia of queyrat: SCC in situ of mucous membranes, uncirc, elderly males, vulva of elderly females and/or oral mucosa, moist red smooth slightly raised plaque. assocaited w/ HPV-8. trx: 5FU, imiquimod

17
Q

pink, pearly, telangectasia, ulceration w/ rolled borders “rodent ulcer”?

MC skin CA and MC malignant neoplasm

complaint bleeding, scabbing, sore, heals and recurs

advances by direct extension and destroys normal tissue

thought to be caused by glasses

treatment?

A

basal cell carcinoma

detect early: excision

detect late: excision, refer to derm and plastics (Mohs)

18
Q

treatment for SCC?

A

small from AK: ED and C

larger and lip: excision w/ margins

examin lymph nodes

F/U q 12 mos

photo-protection

19
Q
A

bowen’s disease

Derm (10 decks)

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