Prelims Flashcards
How much in percentage does the integumentary system make up our body weight?
15-20%
Functions of the integumentary system
Protection
Insulation
Receptors
Aids in Homeostasis
Thermoregulation
Elimination of waste
Synthesis of Vit. D
Oil Production
Cosmesis
Layers of the skin
Epidermis
Dermis
Subcutaneous layer
Water-proof layer of the epidermis that protects the skin against infection
Corneum
Layers of the epidermis
Corneum
Lucidum
Granulosum
Spinosum
Basale
Layer of the epidermis that resists pressure
Lucidum
Where can stratum lucidum be found in the body?
Palms of the hands
Soles of the feet
Layer of the epidermis that functions for water retention
Granulosum
Layer of the epidermis functions for heat regulation
Spinosum
Layer of the epidermis that contains melanocytes
Basale
Another name for stratum basale
Germinativum
Another name for dermis
Corium
How thick is the dermis?
20-30x thicker than the epidermis
What proteins does the dermis contain?
Elastin
Collagen
Normal response to skin turgor
< 5 secs rebound
What structures does the dermis contain?
Receptors
Blood vessels
What are the receptors found in the dermis?
Free-nerve endings
Merkel’s disc
Meissner’s corpuscle
Krause-end bulb
Ruffini endings
Pacinian corpuscle
Another name for the subcutaneous layer
Hypodermis
What does the subcutaneous layer contain?
Fats
Lose connective tissue
Functions of the subcutaneous layer
Support
Insulation
Cushion
Storage of energy
Course and thick hair
Terminal
Fine and short hair
Vellus
Where can terminal hair be found?
Scalp, eyelash, eyebrows, pubic hair
Where can vellus hair be found?
Arm, chest, cheeks
What disease is clubbing of nails indicative of?
Respiratory problem (COPD)
What disease is spoon nails indicative of?
Fungal infection
What disease is white spots in nails indicative of?
Trauma
Another name for sweat glands
Sudoriferous glands
Two types of sweat glands
Eccrine
Apocrine
Function of eccrine glands
Thermoregulation
When is apocrine gland activated?
Emotional stress
Where can apocrine glands be found?
Axilla
Genitals
Beard
Glands that secrete sebum/oil
Sebaceous glands
Muscle responsible for goosebumps
Arrector Pili muscle
Another term for goosebumps
Piloerection
Types of dermatitis
Contact
Actinic
Atopic
Causes of contact dermatitis
Fake jewelries (nickel)
Chromate
Wool fats
Rubber additive
Topical antibiotics
Cause of actinic dermatitis
Sun exposure
S/Sx of acute dermatitis
Redness
Crusting rash
Oozing
S/Sx of subacute dermatitis
Skin erythema
Scaling
Scattered plaques
S/Sx of chronic dermatitis
Thickened skin
Increased skin markings
Post inflammation pigementation
Skin conditions caused by bacterial infection
Impetigo
Cellulitis
Abscess
Bacterial cause of impetigo and cellulitis
Staphylococcus
Streptococcus
Bacterial cause of abscess
Staphylococcus
Management for impetigo
Antibacterials
Management for cellulitis
Oral or topical anitbiotic
Management for abscess
Incision and drainage
Another name for Herpes I
Herpes Simplex
How can Herpes I be transmitted?
saliva
kissing
S/Sx of Herpes I
elevated blisters < 1mm
How can Herpes 2 be transmitted?
Sexual intercourse
What virus is reactivated in Herpes Zoster?
Varicella Zoster
What CN is affected in herpes zoster?
CN III
Another name for warts
Verrucae
What causes warts?
Human Papilloma Virus
Ringworm found in the scalp
Tinea capitis
Ringworm found in the beard
Tinea barbae
Ringworm found in the body
Tinea corporis
Ringworm found in the nail
Tinea ungium
Jock itch
Tinea cruris
Athlete’s foot
Tinea pedis
Parasite that causes scabies
Sarcoptes scabiei
Parasitic infection caused by lice
Pediculosis
Sausage fingers
Dactylitis
S/Sx of psoriasis
Auspitz sign
Erythematous plaques with silvery scales
Skin lesions with proximal muscle atrophy
Polymyositis
A disc shape form of lesion aggravated by sun exposure
Discoid Lupus Erythematosus
A type of lupus wherein all systems are affected and young women are commonly affected
Systemic Lupus Erythematosus
S/Sx of Lupus
Butterfly rash
Anemia
Fatigue/Malaise
Arthritis
Raynaud’s
Progressive systemic sclerosis
Scleroderma
CREST syndrome
Calcinosis
Raynaud’s phenomenon
Esophageal dysfunction
Sclerodactyly
Telangiectasia
Skin color indicative of carbon monoxide poisoning
Cherry red
Skin color indicative of liver problem
Jaundice
Skin color indicative of venous insufficiency
Brown
A condition triggered by exercises, heat, and fever
Hydrosis
S/Sx of Hydrosis
Perfused sweating
Anhidrosis
Coldsweats
Xeroderma
S/Sx of Hypothyroidism
Weight gain
Alopecia
Cold intolerance
Muscle weakness
S/Sx of hyperthyroidism
Weight loss
diarrhea
Exophthalmos
Tachycardia
Granulation of venous ulcer
Bright red
Granulation of arterial ulcer
Pale red
Drainage volume of arterial ulcer
Minimal
Drainage volume of venous ulcer
Moderate to heavy
Location of venous ulcer
Medial malleolus
Location of arterial ulcer
Lateral malleolus
Pain-free position of arterial ulcers
Dependency
Pain-free position of venous ulcers
Elevation
In what type of ulcer is hemosiderin staining present in?
Venous
In what type of ulcer is pedal pulse weak?
Arterial
Where can diabetic ulcers be found?
Lateral malleolus
Plantar aspect of MTT head
Best gait pattern for pts with diabetic neuropathy
3-point gait
Stage of presure ulcer where only the epidermis is affected and there non-blanchable erythema
Stage I
Stage of presure ulcer where dermis is also affected and there is partial thickness loss and a presence of a shallow crater
Stage II
Stage of presure ulcer where the subcutaneous tissue is affected and there’s a presence of a deep crater
Stage III
Stage of pressure ulcer where muscle and bones are already exposed
Stage IV
A warty spot caused by proliferation of basal cells resulting in a raised lesion
Seborrheic keratosis
A scaly skin condition caused by proliferation of squamous cells
Actinic keratosis
A skin condition caused by proliferation of melanocytes
Common mole
Another name for common mole
Benign nevus
A type of skin cancer that is slow-growing, ivory in appearance, and caused by sun-exposure
Basal cell carcinoma
A type of skin cancer that is fast-growing, has a poorly-definer border, and caused by sun exposure
Squamous cell carcinoma
A tumor arising from melanocyte
Malignant melanoma
Size of malignant melanoma
> 6mm
ABCDE of melanoma
Asymmetry
Border
Color
Diameter
Evolving
Basic unit of life
Cell
Functions of cell
Transport, diffuse, osmosis
Cellular communication
Energy production
Solid part of the cell
Organelles
Liquid part of the cells
Cytoplasm
Negative ions
Anion
Positive ions
Cation
Notable cations
Sodium
Potassium
Calcium
Notable anions
Magnesium
Proteins
A condition wherein there is increased sodium in blood
Hypernatremia
Risk factors of hypernatremia include
DM
Increased aldosterone
Water loss
S/Sx of hypernatremia
Fever
Dehydration
Ms twitching
Restlessness
A condition wherein there is decreased sodium in blood
Hyponatremia
Risk factors of hyponatremia include
Diarrhea
Vomitting
S/Sx of hyponatremia
Seizure
A condition wherein there is increased potassium in blood
Hyperkalemia
S/Sx of hyperkalemia
Ms paralysis
Decreased ms tone
Cardiac dysfunction
A condition wherein there is decreased potassium in blood
Hypokalemia
Risk factors of hypokalemia include
Excessive intake of carbs
Excessive alcohol intake
Diarrhea
Vomiting
Perfused sweating
S/Sx of Hypokalemia
Skeletal ms weakness
Ventricular arrythmia
A condition wherein there is increased calcium in blood
Hypercalcemia
Risk factors for hypercalcemia include
Hyperparathyroidism
Cancer
S/Sx of hypercalcemia
Osteoporosis
Fractures
A condition wherein there is decreased calcium in blood
Hypocalcemia
Risk factors for hypocalcemia include
Multiple blood transfusions
S/Sx of hypocalcemia
Cardiac arrest
Powerhouse of the cell and responsible for ATP synthesis
Mitochondria
Lipid bilayer of the cell
Cell membrane
Organelle that contains our DNA
nucleus
Organelle that contains our RNA
Nucleolus
It is where ribosomes are found
Rough ER
Organelle where lipid synthesis occurs
Smooth ER
Organelle that sorts and transports proteins to targeted destinations
Golgi apparatus
Organelle that digests and recycles cellular materials
Lysosome
Organelle that breaks down free radicals
Peroxisomes
Stages of mitosis
Prophase
Metaphase
Anaphase
Telophase
Preparatory phase of mitosis wherein chromatids condenses into visible chromosomes
Prophase
Phase of mitosis wherein the chromosomes are aligned in the middle of the cell
Metaphase
Phase of mitosis wherein the sister chromatids are pulled apart or separated
Anaphase
Phase of mitosis wherein there is formation of two daughter cells
Telophase
Transport mechanism that moves molecules from higher to lower concentration grade
Diffusion
Transport mechanism that diffuses water through a semi-permeable membrane
Osmosis
Subtypes of passive transport
Diffusion
Osmosis
Facilitated diffusion
Another name for diffusion
Downhill transport
Differentiate simple diffusion and facilitated diffusion
Simple: moves through phospholipid bilayer
Facilitated: moves through membrane via specific transport/carrier proteins
What molecules go through simple diffusion?
Small, non-polar molecules like oxygen, CO2, Methane
What molecules go through facilitated diffusion?
Large, polar molecules like glucose, ions, carbon monoxide
Type of transport mechanism that goes from low to high concentration grade
Active transport
Another name for Active transport
Uphill transport
A subtype of active transport that uses ATP to go against concentration grade
Primary AT
A subtype of active transport that uses energy stored in cell to go against concentration grade
Secondary AT
Example of primary AT
Na-K pump
Factors that increase diffusion rate
Increased temperature
Small molecular size
Increased partition coefficient
Star-shaped cells in neurons that provide structural support
Astrocytes
These cells serve as the myelin sheath of the CNS
Oligodendrocytes
These cells serve as the myelin sheath of the PNS
Schwann’s cell
These cells line the choroid plexus
Ependymal cells
These cells serve as protection of the neurons
Microglia
Resting membrane potential of the nerve
-70 mV
Resting membrane potential of muscles and heart
-90 mV
Rapid changes within a cell
Action potential
Charge during resting membrane potential (RMP)
negative (-)
Charge during depolarization
positive (+)
Charge during repolarization
positive (+)
Molecule movement during RMP
no movement
Molecule movement during depolarization
Na+ influx
Molecule movement during repolarization
K+ efflux
Principles of action potentials
All or none
Saltatory conduction
Absolute Refractory period
Relative Refractory period
A condition affecting the NMJ that has a post-synaptic affectation
Myasthenia gravis
A condition affecting the NMJ that has a pre-synaptic affectation
Lambert-Eaton Myasthenia Gravis (LEMS)