PRELIM LEC 2: CELLS AND THE CELL CYCLE Flashcards
Biological science of cell
CYTOLOGY
BASIC UNIT OF LIFE
CELL
- body cells
- have 2 copies of the genome
- DIPLOID (46 chromosomes)
A STEM CELLS
B GERM CELLS
C SOMATIC CELLS
C SOMATIC CELLS
- sperm and egg cells
- have 1 copy of the genome
- HAPLOID (23 chromosomes)
-1 set of chromosomes. - Return to diploid state through FERTILIZATION.
A STEM CELLS
B GERM CELLS
C SOMATIC CELLS
B GERM CELLS
- diploid cells that divide to give the rise to different cells
- enable a body to develop, grow, and repair damage.
A STEM CELLS
B GERM CELLS
C SOMATIC CELLS
A STEM CELLS
The sum of all chemical reactions.
- Can be ANABOLISM or CATABOLISM.
- Happens in the MITOCHONDRIA
METABOLISM
- variety of cell types and surrounding materials protect, support, bind to cells,
and fill spaces throughout the body; - include cartilage, bone, blood, and fat
A NERVOUS
B MUSCLE
C EPITHELIUM
D CONNECTIVE TISSUES
CONNECTIVE TISSIUES
- Tight cell layers form linings that protect,
- secrete, absorb, and excrete
A NERVOUS
B MUSCLE
C EPITHELIUM
D CONNECTIVE TISSUES
C EPITHELIUM
- Cells contract, providing movement
A NERVOUS
B MUSCLE
C EPITHELIUM
D CONNECTIVE TISSUES
B MUSCLE
- Neurons transmit information as electrochemical impulses that coordinate movement and also sense and respond to environmental stimuli
A NERVOUS
B MUSCLE
C EPITHELIUM
D CONNECTIVE TISSUES
A NERVOUS
support and nourish neurons
NEUROGLIA
MAJOR DOMAINS OF LIFE
- Single celled (prokaryotes).
- Lives and strive in HOT PLACES (THERMOPHILIC) can be at the bottom of the sea
A BACTERIA
B ARCHAEA
C EUKARYA
B ARCHAEA
MAJOR DOMAINS OF LIFE
Prokaryotic cells, No nucleus.
A BACTERIA
B ARCHAEA
C EUKARYA
A BACTERIA
MAJOR DOMAINS OF LIFE
this group includes single-celled organisms that have nuclei, as well as all multicellular organisms (fungi, plants, animals, humans and others)
A BACTERIA
B ARCHAEA
C EUKARYA
C EUKARYA
major macromolecules that make up cells and that cells use as fuel are
CARBOHYDRATES
PROTEINS
LIPIDS
NUCLEIC ACIDS
- provide energy and contribute to cell structure
A CARBOHYDRATES
B PROTEINS
C LIPIDS
D NUCLEIC ACIDS
A CARBOHYDRATES
form the basis of some hormones, form
membranes, provide insulation
- Used for insulation, keeping the right temperature
- and for energy storage, performed by ADIPOSE TISSUE
A CARBOHYDRATES
B PROTEINS
C LIPIDS
D NUCLEIC ACIDS
C LIPIDS
- enable blood to clot
- form the contractile fibers of muscle cells (ACTIN & MYOSIN)
- form the bulk of the body’s connective tissues (collagen)
A CARBOHYDRATES
B PROTEINS
C LIPIDS
D NUCLEIC ACIDS
B PROTEINS
- Most important to the study of genetics (DNA & RNA)
- translate information from past generations into specific collections of proteins that give a cell its characteristics.
A CARBOHYDRATES
B PROTEINS
C LIPIDS
D NUCLEIC ACIDS
D NUCLEIC ACIDS
- are especially important proteins because they facilitate, or catalyze, biochemical reactions so that they occur fast enough to sustain life.
- speed specific chemical reactions by lowering the “activation energy” required to start the
ENZYMES
Present is small amounts
MICROMOLECULES
MICROMOLECULES
Energy production
Antioxidant defense
DNA synthesis and repair
Cellular communication
Immune function
Cellular structure and integrity
VITAMINS AND MINERALS
PROBLEMS IN METABOLISM
- Genetic diseases result from deficient/absent of enzymes that affect major types of biomolecules
INBORN ERRORS OF METABOLISM
PROBLEMS IN METABOLISM
(carbohydrates)
Lacks enzyme lactase, which breaks down lactose into glucose and galactose.
A LACTASE DEFICIENCY/LACTOSE INTOLERANCE
B FAMILIAL HYPERCHOLESTEROLEMIA
C MAPLE SYRUP URINE DISEASE (MSUD)
D LESCH-NYHAN SYNDROME
LACTASE DEFICIENCY/LACTOSE INTOLERANCE
PROBLEMS IN METABOLISM
(LIPIDS)
- Genetic defect, which resulted to inability to metabolize cholesterol.
- LDL – Low Density Lipoproteins (Bad cholesterol) accumulates in the blood vessel
A LACTASE DEFICIENCY/LACTOSE INTOLERANCE
B FAMILIAL HYPERCHOLESTEROLEMIA
C MAPLE SYRUP URINE DISEASE (MSUD)
D LESCH-NYHAN SYNDROME
FAMILIAL HYPERCHOLESTEROLEMIA
PROBLEMS IN METABOLISM
(LIPIDS)
Deficiency of HGPRT
Inability to recycle purines, which are part of nucleic acids that are found in nucleotides.
Purine turns into uric acid if not recycled.
It crystalizes in the urine, resulting to kidney stones.
It also accumulates in the joints causing gout arthritis.
A LACTASE DEFICIENCY/LACTOSE INTOLERANCE
B FAMILIAL HYPERCHOLESTEROLEMIA
C MAPLE SYRUP URINE DISEASE (MSUD)
D LESCH-NYHAN SYNDROME
LESCH-NYHAN SYNDROME
Inability of the liver to control the excess copper that the digestive tract absorbed from the food such as meat, leafy vegetables and guts.
Accumulates in the liver, which cause hepatomegaly (enlargement of the liver).
KAYSER-FLEISCHER RING
GREEN/YELLOW RING IN THE EYE ring in the eye (cornea) which are the deposits of excess copper
WILSON DISEASE
CELL ORGANELLES
- most prominent organelle of most cells
- contains DNA complexed with many proteins to form chromosomes.
- genetic headquarters
NUCLEUS
CELL ORGANELLES
surrounds the nucleus.
NUCLEAR ENVELOPE
CELL ORGANELLES
- Biochemicals can exit or enter the nucleus through
- are rings of several types of proteins around an opening, like lined portholes in a ship’s side
NUCLEAR PORES
CELL ORGANELLES
- On the inner face of the nuclear membrane is a layer of fibrous material called the ___
- not just an inert covering, but turns off the expression of genes that contact it from within.
- also provides mechanical support and holds the nuclear pores in place.
NUCLEAR LAMINA
CELL ORGANELLES
- - Inside the nucleus is an area that appears darkened under a microscope, called the ____
- here, ribosomes are produced
NUCLEOLUS
CELL ORGANELLES
- The fluid in the nucleus, minus these contents, is called _______
NUCLEOPLASM
CELL ORGANELLES
-cytoplasm is also called ____ when other cellular components are removed
CYTOSOL
- is the release of a substance from a cell, illustrates one way that organelles function together.
A ENERGY PRODUCTION
B SECRETION
C DIGESTION
B SECRETION
the epithelial cells found in the breast are called____ that form tubules, into which they secrete the components of milk
LACTOCYTES OR MILK CELLS
a lack of the enzyme lactase
LACTASE DEFICIENCY
- a type of transport of molecules between cells uses vesicles
- bud from one cell and then travel to, merge with, and empty their contents into other cells.
- are only 30 to 100 nanometers (billionths of a meter) in diameter.
- remove debris, transport immune system molecules, and provide a vast communication network among cells.
EXOME
- (“bodies that cut”) handle the garbage.
- are membrane-bounded sacs that contain enzymes that dismantle bacterial remnants, worn-out organelles, and other material such as excess cholesterol
- TRASH CENTERS
- fuse with vesicles carrying debris from outside or within the cell, and the lysosomal enzymes then degrade the contents.
LYSOSOMES
The cell’s disposing of its own trash is called
AUTOPHAGY (eating self)
a type of vesicle that forms from the plasma membrane, called an _________,
ferries extra low-density lipoprotein (LDL) cholesterol to lysosomes.
ENDOSOMES
Cells called _________ that move about and engulf bacteria have many lysosomes.
Liver cells require many lysosomes to break down cholesterol, toxins, and drugs.
MACROPHAGES
All lysosomes contain ____ types of digestive enzymes, which must be maintained in balance.
43
Absence or malfunction of an enzyme causes a __________, in which the molecule that the missing or abnormal enzyme normally degrades accumulates.
LYSOSOMAL STORAGE DISEASE
In __________, an ENZYME IS DEFICIENT THAT NORMALLY BREAKS DOWN LIPIDS IN THE CELLS THAT SURROUND THE NERVE CELLS. As the nervous system becomes buried in lipid, the infant begins to lose skills, such as sight, hearing, and mobility.
TAY-SACHS DISEASE