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QC 1 LEC & LAB > PRELIM LAB > Flashcards

PRELIM LAB Flashcards

1
Q

MANIFESTATION OF DEFECTIVE PRODUCT?

A

improper labeling
discoloration
presence of cloudiness
presence of crystals
presence of precipitates

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2
Q

defined as the sum of all factors which contributes directly or indirectly to the safety, effectiveness and reliability of the product

A

QUALITY

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3
Q

refers to the sum of all the procedures undertaken to ensure the identity and purit of a particularly pharmaceutical product

A

qualty control

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4
Q

QC control gurantees within reasonable limits that a drug product

A

free from impurities
physically and chemically stable
contains the amount of active ingr. as stated in the label
provides optimal release of active ingr. when product is administered

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5
Q

the chemical substance being analyzed

A

analyte or active constituents

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6
Q

solution of a known concentration

A

titrant

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7
Q

chemical which changes color at the very near the equivalent

A

indicator

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8
Q

theoretical point at which equivalent amounts of analyte and titrant have reacted

A

equivalence point or stoichiometric point

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9
Q

point at which there occurs a sudden change in some property of the reaction mixture

A

end point

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10
Q

determination of normality or molarity of a solution

A

standardization

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11
Q

conc. expression and is defined as the number of equivalents of solute per liter or milliequivalents per ml of a soln

A

normality

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12
Q

expression of conc. of a soln. in terms of moles per liter

A

MOlarity

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13
Q

highly purified 99.99% ultrapure compound that serves as reference material in titration

A

primary standard

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14
Q

a compound whose purity 97-98% has been established by careful chemical analysis

A

SECONDARY STANDARD

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15
Q

the diff in volume or mass between the endpoint ans equivalence point

A

Titration error

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16
Q

sometimes it is necessary to add an excess of the standard titrant and the excess amount is titrated w/ a second standard titrant

A

back titration

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17
Q

direct addition of titrant to analyte

A

direct titration

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18
Q

adding excess amount of acid to a base to quatify w/base

A

residual titration(back titration)

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19
Q

needs to perform pre-treatment before titration

A

indirect titration

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20
Q

correcting errors, repeating the assay w/o the analyte

A

blank titration

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21
Q

acid yellow base violet

A

bromophenol blue

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22
Q

orange;yellow

A

methyl orange

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23
Q

yellow;blue

A

chlorophenol blue

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24
Q

yellow;blue

A

bromothymol blue

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25
Q

yellow;red

A

cresol red

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26
Q

colorless;red

A

phenolphthalein

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27
Q

principle in prep and standardization of hcl soln

A

neutralization-Alkalimetry

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28
Q

what prep is this based from chemical equation
2hcl + na2co3 -> 2Nacl + CO2 + h2o

A

Prep and standardization of hcl

29
Q

titrant in experiment 1

A

hcl soln

30
Q

analyte in experiment 1

A

anhydrous sodium carbonate (Na2CO3)

31
Q

INDICATOR AND END POINT IN EXPERIMENT 1

A

METHYL ORANGE AND SALMON PINK ENDPOINT

32
Q

WHAT IS EXPERIMENT 2

A

PREP AND STANDARDIZATION OF SODIUM HYDROXIDE SOLN

33
Q

PRINCIPLE INVOLVED IN EXPERIMENT 2

A

NEUTRALIZATION ACIDIMETRY

34
Q

TITRANT IN EXP 2

A

SODIUM HYDROXIDE SOLN

35
Q

ANALYTE IN EXP 2

A

HCL

36
Q

INDICATOR AND ENDPOINT IN EXP 2

A

PHENOLPTHALEIN AND LIGHT PINK COLOR ENDPOINT

37
Q

refers to qualitatively assesig or quantitavely measuring the presence of, amount or functional activity of a target entity

A

assay

38
Q

aspirin or?

A

acetylsalicylic acid

39
Q

classification and uses of aspirin and side effects

A

NSAIDs
analgesic (pain relief)
antipyretic (reduces fever)
anti-inflammatory(inhibition of the synthesis of prostaglandins)
irritation of stomach or gut, indigestion and nausea

40
Q

titrant for aspirin assay

A

hcl sln

41
Q

analyte for aspirin assay

A

aspirin w/ sodium hydroxide soln

42
Q

indicator and end point

A

phenolpthalein and disapearance of pink color

43
Q

determination of volume of soln of a known conc.

A

volumetric soln

44
Q

based on physical and chemical prop. of substance being analyzed

A

physiocolchemical analysis

45
Q

separation by extraction, ppt, or other means of the constituents to be determined either in the natural state or in the form of definite compound

A

Gravimetric analysis

46
Q

alkaloidal assaying, siponification

A

special methods

47
Q

techniques used in physiocochemical analysis

A

chromatography
spectrophtometric
electrometric
therma condumetric
refratometric
polarimetric

48
Q

manifest themselves
difficult to detect such as difference in judgement and skill of the analyst
intangible

A

indeterminate error

49
Q

nature that occur in constancr manner in each of a series of determinations
personal error
apparatus error
poor calibration
detectable and may be eliminated

A

determinate error

50
Q

from where is the british pharmacopoeia and what 3 cities

A

from great britain
london, dublin, edinburgh

51
Q

1st american pharmacopoeia

A

lititz pharmacopoeia

52
Q

who published lititz pharmacopoeia/father of USP and what date he submitted a plan for the creation of it

A

dr. lyman spalding
jan. 6 1817

53
Q

homeopathic pharmacopoeia of US and used the principle of similarities

A

dr. samuel hahnermann

54
Q

intl. pharmacopoeia

A

WHO

55
Q

YEAR THAT LITITZ WAS USED IN US ARMY

A

1778

56
Q

MASSACHUSETTS MED SOCIETY PUBLISHED __ PAGES PHARMACOPOEIA ON MONOGRAPHS ON ___ DRUGS OF PHARMACEUTICAL PREPARATIONS AND WHAT YEAR

A

272 PAGES, 536 DRUGS AND 1808

57
Q

DATE WHEN DRAFT PHARMACOPOEIA WAS CONSOLIDATED

A

JAN 1 1820

58
Q

DATE WHEN USP ENG AND LATIN WAS PUBLISHED

A

DEC 15 1820

59
Q

1ST ED. OF NF UNOFFICIAL PREPARATIONS WAS PUBLISHED

A

1888

60
Q

PHARMACOP. GRABT AUTHORITY FOR SUPPLEMENTS TO USP

A

1990

61
Q

DATE THE TITLE NATIONAL FORMULARY OF UNOFFICIAL PREPARATIONS WAS CHANGED TO NF, WHO WAS THE PRES. AND WHAT ACT

A

JUNE 30, 1906
PRES. THEODORE ROOSEVELT
PURE FOOD AND DRUG ACT

62
Q

YEAT USP DECIDED TO REVISE USP EVERY 5 YRS AND NF 10 YRS

A

1940 BUT NOW ITS ANNUALLY REVISED

63
Q

YEAR USP PURCHASED NF

A

1975

64
Q

1ST COMBINED COMPENDIUM WHAT USP , NF AND DATE

A

USP XX AND NF XV
JULY 1 1980

65
Q

WHAT ED. OF USP AND NF WAS USED TO CHANGE FROM ROMAN TO ARABIC DICTATE EDITIONS AND WAHT YR

A

USP 23 AND NF 18
1995

66
Q

YR USP-NF BECAME AN ANNUAL PUBLICATION

A

2002

67
Q

principles involved in assay of aspirin

A

Neutralization and saponification of esters

68
Q

ester cleaved back into carboxylic acid and an alcohol by reactions of water and base

A

Saponification

QC 1 LEC & LAB (3 decks)

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