Prelim drugs Flashcards
1
Q
Drug Name
A
Drug Class Mechanism Distinguishing Chem Characteristics (Unique or "weird" features) Pharmacological characteristics Side Effects Special side effects Use [mnemonic] (put in brackets)
2
Q
cyclophosphamide
A
-alkylating agents (bischoloroethyl amines)
3
Q
mechlorethamine
A
-alkylating agents (bischoloroethyl amines)
4
Q
nitrosureas
A
-alkylating agents
5
Q
procarbazine
A
-alkylating agents (other)
6
Q
cisplatin
A
-platinum coordination complexes
7
Q
methotrexate
A
-anti-tumor antimetabolites
8
Q
leucovorin
A
-anti-tumor antimetabolites (folinic acid rescue)
9
Q
5-fluorouracil
A
- anti-tumor antimetabolites
- pyrimidine antagonist
10
Q
capecitabine
A
- anti-tumor antimetabolites
- pyrimidine antagonist
11
Q
cytosine arabinoside (cytarabine, ara C)
A
- anti-tumor antimetabolites
- pyrimidine antagonist
12
Q
6-mercaptopurine
A
- anti-tumor antimetabolites
- purine antagonist
13
Q
6-thioguanine
A
- anti-tumor antimetabolites
- purine antagonist
14
Q
bleomycin
A
-anti-tumor antibiotics
15
Q
daunorubicin
A
-anti-tumor antibiotics, topoisomerase inhibitors
16
Q
doxorubicin
A
-anti-tumor antibiotics, topoisomerase inhibitors
17
Q
paclitaxel
A
-mitotic spindle poisons
18
Q
vinblastine
A
-mitotic spindle poisons (vinca alkaloids)
19
Q
vincristine
A
-mitotic spindle poisons (vinca alkaloids)
20
Q
irinotecan
A
-topoisomerase inhibitors (camptothecins)
21
Q
topotecan
A
-topoisomerase inhibitors (camptothecins)
22
Q
daunorubicin
A
-anti-tumor antibiotics, topoisomerase inhibitors
23
Q
doxorubicin
A
-anti-tumor antibiotics, topoisomerase inhibitors
24
Q
etoposide
A
-topoisomerase inhibitors
25
tamoxifen
-antagonist of hormone action
26
raloxifene
-antagonist of hormone action
27
anastrozole
-antagonist of hormone action
28
letrozole
-antagonist of hormone action
29
exemestane
-antagonist of hormone action
30
leuprolide
-antagonist of hormone action
31
flutamide
-antagonist of hormone action
32
prednisone
-adrenocorticosteroids
33
lapatinib
-"Targeted" agents (EGFR kinase inhibitors)
34
erlotinib
-"Targeted" agents (EGFR kinase inhibitors)
35
lapatinib
-"Targeted" agents (HER2 kinase inhibitor)
36
imatinib
-"Targeted" agents (bcr/abl kinase inhibitor)
37
cetuximab
-"Targeted" agents (chimeric/humanized antibodies)
38
trastuzumab
-"Targeted" agents (chimeric/humanized antibodies)
39
brentuximab vedotin
-"Targeted" agents (chimeric/humanized antibodies)
40
Drug Name
```
Drug Class
Mechanism
Distinguishing Chem Characteristics (Unique or "weird" features)
Pharmacological characteristics
Side Effects
Special side effects
Use
[mnemonic] (put in brackets)
```
41
Morphine
-Opioid agonist
-Mu receptor
-
-
-sedate, constipate, resp depress, nausea/vomit
-euphoria, miosis
-Analgesia
42
Drug Name
```
Drug Class
Mechanism
Distinguishing Chem Characteristics (Unique or "weird" features)
Pharmacological characteristics
Side Effects
Special side effects
Use
[mnemonic] (put in brackets)
```
43
amitriptyline
- tricyclics (TCA's)
- block ser & NE reuptake
- block histamine, muscarinic, adrenergic R's.
- 2 weeks to work, long half-life, kidney elim & bit hepatic microsomes
- antimuscarinic, sedation (H1 R), sex down, weight up, delirium, tachycardia
- seizures, slowing A-V conductance, orthostatic hypotension (alpha 1 R)
- Antidepressant
44
amoxapine
- tricyclics (TCA's)
- block ser & NE reuptake
- block histamine, muscarinic, adrenergic R's.
- 2 weeks to work, long half-life, kidney elim & bit hepatic microsomes
- antimuscarinic, sedation (H1 R), sex down, weight up, delirium, tachycardia
- seizures, slowing A-V conductance, orthostatic hypotension (alpha 1 R)
- Antidepressant
45
imipramine
- tricyclics (TCA's)
- block ser & NE reuptake
- block histamine, muscarinic, adrenergic R's.
- 2 weeks to work, long half-life, kidney elim & bit hepatic microsomes
- antimuscarinic, sedation (H1 R), sex down, weight up, delirium, tachycardia
- seizures, slowing A-V conductance, orthostatic hypotension (alpha 1 R)
- Antidepressant
46
nortriptyline
- tricyclics (TCA's)
- block ser & NE reuptake
- block histamine, muscarinic, adrenergic R's.
- 2 weeks to work, long half-life, kidney elim & bit hepatic microsomes
- antimuscarinic, sedation (H1 R), sex down, weight up, delirium, tachycardia
- seizures, slowing A-V conductance, orthostatic hypotension (alpha 1 R)
- Antidepressant
47
citalopram
- SSRI's
- block ser reuptake
- neurogenesis in hippocampus (via BDNF)
- 2 wks to work, kidney elim, block P450, high first-pass effect, binds plasma proteins
- nausea, anxiety, insomnia... late: sex down
- late: anorexia, mania
- Antidepressant
48
escitalopram
- SSRI's
- block ser reuptake
- neurogenesis in hippocampus (via BDNF)
- 2 wks to work, kidney elim, block P450, high first-pass effect, binds plasma proteins
- nausea, anxiety, insomnia... late: sex down
- late: anorexia, mania
- Antidepressant
49
fluoxetine
- SSRI's
- block ser reuptake
- neurogenesis in hippocampus (via BDNF)
- demethylated to active. 2 wks to work, kidney elim, block P450, high first-pass effect, binds plasma proteins
- nausea, anxiety, insomnia... late: sex down
- late: anorexia, mania
- Antidepressant
50
sertraline
- SSRI's
- block ser reuptake
- neurogenesis in hippocampus (via BDNF)
- 2 wks to work, kidney elim, block P450, high first-pass effect, binds plasma proteins
- nausea, anxiety, insomnia... late: sex down
- late: anorexia, mania
- Antidepressant
51
duloxetine
-SNRI's
-block ser, NE reuptake (but UNRELATED to TCA's)
-
-1/4 bound to plasma proteins, elim mostly kidney. metab by CYP1A2, CYP2D6
-nausea, anxiety, insomnia, sex down [same as SSRI's!]
-high dose up blood pressure
-depression refractory to SSRI's
52
venlafaxine
-SNRI's
-block ser, NE reuptake (but UNRELATED to TCA's)
-
-mostly bound to plasma proteins, elim mostly kidney. metab by CYP2D6
-nausea, anxiety, insomnia, sex down [same as SSRI's!]
-high dose up blood pressure
-depression refractory to SSRI's
53
bupropion
-atypicals
54
mirtazapine
-atypicals
55
nefazodone
-atypicals
56
phenelzine
-MAOi's
57
selegiline
-MAOi's
58
tranylcypromine
-MAOi's
59
lithium
-bipolar treatment
60
carbamazepine
-bipolar treatment
61
olanzapine
-bipolar treatment
62
risperidone
-bipolar treatment
63
valproic acid
-bipolar treatment
64
amphetamine
-Stimulants
65
atomoxetine
-Stimulants
66
dextro-amphetamine
-Stimulants
67
methylphenidate
-Stimulants
68
modafinil
-Stimulants
