16 Vasculitis Flashcards
Giant Cell (Temporal) arteritis affects what group most commonly?
Over 50. Especially Northern Europeans.
Giant Cell (Temporal) arteritis affects which arteries?
temporal, vertebral, ophthalmic, aorta
[group as mostly “arteries of the head”]
T/F temporal arteritis can cause permanent blindness?
T. (ophthalmic artery)
Suspected etiology/pathogenesis temporal arteritis?
Unknown. Suspected: immune rxn against arterial wall protein, probably T-cell mediated (granulomatous)
Symptoms of temporal arteritis?
fever, fatigue, weight loss, abrupt diplopia or vision loss
[note most are non-specific]
Treatment temporal arteritis?
high-does anti-inflammatories (steroids)
Risk factors: Takayasu arteritis? (2)
- female under 40 (8:1, f:m)
- HLA -A24, B52, DR2
Incidence: Takayasu arteritis? (2)
- US: 1/1000
- Asia: 6/1000
Giant Cell (Takayasu) arteritis: affects what body parts? (3) How?
- Ascending aorta “Pulseless disease”
- Can also involve pulmonary & renal arteries
- Fibrosis of artery wall ->stenosis-> occlusion->dilation-> aneurysm
Giant cell (Takaysu) arteritis: signs early & late phases?
- Early: fever, arthalgias, weight loss, “prepulseless”
- Late: “Pulseless”
Type 1 Takayasu Arteritis is?
branchiocephalic trunk, carotid arteries & subclavian
Type 2 Takayasu Arteritis is?
combined Type 1 & Type 3
Type 3 Takayasu Arteritis is?
“atypical coarctation type” involves thoracic & abdominal aorta (most common!!)
Type 4 Takayasu Arteritis is?
“Dilated type”, dilation of aorta & its major branches
Takayasu arteritis: treatment? (2)
- steroids
- angioplasty (after acute phase)
