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[1ST YEAR] PH 105.1 - Pharmaceutical Analysis I (Lab) > PRELIM 01 - Introduction to Pharmaceutical Analysis > Flashcards

PRELIM 01 - Introduction to Pharmaceutical Analysis Flashcards

1
Q

Application of the procedures of quantitative analytical chemistry

A

Quantitative pharmaceutical chemistry

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2
Q

Person responsible for initiating the steps to determine if the product is defective

A

Pharmacist

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3
Q

5 manifestations of a defective product

A

Improper labeling, Discoloration, Presence of cloudiness, Presence of crystals, Presence of precipitates

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4
Q

Defined as the sum of all factors which contribute directly or indirectly to the safety, effectiveness, and reliability of the product

A

Quality

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5
Q

Defined as the sum of all procedures undertaken to ensure the identity and purity of a particular pharmaceutical

A

Quality control

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5
Q

Pharmacopoeia originating from Great Britain; formed by combining London, Edinburgh, and Dublin’s pharmacopoeias in 1864

A

British Pharmacopoeia

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5
Q

First US pharmacopoeia published in 1778

A

Lititz Pharmacopoeia

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5
Q

Father of the United States pharmacopoeia who suggested the idea of a pharmacopoeia to the medical society of New York

A

Dr. Lyman Spalding

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5
Q

Used to be a revolt/rebellious record first coined as the “National Formulary of Unofficial Preparations”

A

National Formulary

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6
Q

Was exclusive to doctors and was held every 10 years

A

USP convention

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7
Q

President that declared USP & NF as standards for medicinal and pharmacopoeial substances

A

President Theodore Roosevelt

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8
Q

Coined by Samuel Hahnemann and was based on the law of similarities

A

Homeopathic Pharmacopoeia of the US

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9
Q

Coined the Homeopathic Pharmacopoeia of the US

A

Samuel Hahnemann

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10
Q

Published by the WHO and serves as a recommendation to national pharmacopoeia revisions

A

International Pharmacopoeia

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11
Q

Year when the Lititz Pharmacopoeia (first American pharmacopoeia) was published for use

A

1778

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12
Q

Year when the Massachusetts Medical Society published a 272-page pharmacopoeia containing information on 536 drugs

A

1808

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13
Q

Date when Dr. Lyman Spalding (father of USP) submitted a plan to the medical society of the county of New York

A

January 6, 1817

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14
Q

Date when draft pharmacopoeias were reviewed, consolidated, and adopted by the first USP convention in Washington DC

A

January 1, 1820

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15
Q

Date when the first USP was published in English and Latin

A

December 15, 1820

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16
Q

Year when the first edition of the National Formulary for Unofficial Preparations was published

A

1888

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17
Q

Year when the pharmacopoeial convention granted authority to issue supplements to the USP

A

1900

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18
Q

Date when the title “National Formulary of Unofficial Preparations” was changed to “National Formulary”

A

June 30, 1906

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19
Q

The act that President Roosevelt signed into law

A

Pure Food and Drug Act

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20
Q

Year when the USP convention decided to revise the USP every 5 years and revise the NF every 10 years

A

1940

21
Q

Year when the USP Convention, Inc. purchased the NF

A

1975

22
Q

Date when the first combined compendium, comprising of the USP XX and NF XV, became official

A

July 1, 1980

23
Q

Year when the USP 23/NF 18 became the first edition to drop the use of roman numerals in favor of Arabic numerals

A

1995

24
Q

Year when the USP/NF became an annual publication

A

2002

25
Q

Determination of the volume of a solution of known concentration

A

Volumetric analysis

26
Q

Based on some physical or chemical properties of a substance

A

Physicochemical methods

27
Q

6 examples of instrumental techniques

A

Chromatographic, Spectrophotometric, Electrometric, Thermal conductimetric, Refractometric, Polarimetric

28
Q

Separation by extraction, precipitation, or other means of the constituents to be determined

A

Gravimetric analysis

29
Q

Those methods which require a distinct type of technique

A

Special methods

30
Q

3 examples of special methods

A

Alkaloidal assaying, Saponification value, Acid value

31
Q

Used to denote the agreement of an experimental result

A

Accuracy

32
Q

Measure of the reproducibility of date within a series of results

A

Precision

33
Q

2 types of errors

A

Indeterminate/Noise/Random error, Determinate error

34
Q

Slight variations in a series of observations made by the same observer under identical conditions

A

Indeterminate/Noise/Random error

35
Q

Nature that recur in constant manner in each of a series of determinations

A

Determinate error

36
Q

Chemical being analyzed

A

Analyte/Active constituent

37
Q

Solution of known concentration

A

Titrant

38
Q

Analytical method in which the volume of a solution of known concentration during analysis is taken as a measure of the amount of active constituent in a sample being analyzed

A

Titration

39
Q

Chemical which changes color at a point very near the equivalence point

A

Indicator

40
Q

Theoretical point at which equivalent amounts of analyte and titrant have reacted

A

Equivalence point/Stoichiometric point

41
Q

Point at which there occurs a sudden change in some property of the mixture

A

End point

42
Q

Determination of normality or molarity of a solution

A

Standardization

43
Q

Concentration expression that is defined as the number of equivalents of solute per liter

A

Normality

44
Q

Concentration expression of solution in terms of moles per liter

A

Molarity

45
Q

Solution of known normality or molarity

A

Standard solution

46
Q

Highly purified (about 99.99% /ultrapure) compound that serves as a reference material in titration

A

Primary standard

47
Q

Purity (97.88%) has been established by careful chemical analysis

A

Secondary standard

48
Q

Difference in volume and mass between the end point and equivalence point

A

Titration error

49
Q

Direct addition of a titrant to analyte

A

Direct titration

50
Q

Adding excess amount of acid to base to quantify with base

A

Residual/back titration

51
Q

Needs to perform pre-treatment before titration

A

Indirect titration

52
Q

Correcting errors, repeating the assay without the analyte

A

Blank titration

53
Q

A reaction where an acid reacts with a base

A

Neutralization reaction

54
Q

2 products of a neutralization reaction

A

Water, Salt

[1ST YEAR] PH 105.1 - Pharmaceutical Analysis I (Lab) (5 decks)

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