Pregnancy Drugs (Lauren 🌭) Flashcards
Things (change/stay the same) in pregnant women
Change
Drug absorption, metabolism, and excretion all change
Total blood volume increases
When you give a pregnant woman a drug, what assumption should you make?
The baby is going to be exposed to it too
What is the example of a category A drug that she gave in class?
Folic acid
Which category A drug is RECOMMENDED for all pregnant women women of childbearing age to take?
Folic acid
Does the placenta metabolize things?
Yes it can
What are some REALLY important features of a drug that affect how much it will cross the placenta?
Molecular size
pH
Why is it pretty safe to give heparin to pregnant women?
It is a HUGE, POLAR molecule that will not cross the placenta
If a you took some teratogenic drug while you were pregnant, and then when you deliver it, the baby comes out normal and healthy, are you out of the woods?
NO. teratogenic effects are not always seen immediately!!
What is an example of a drug that caused problems many years later for people who were exposed to it in utero?
Diethylstilbestrol (DES)- caused cervical and vaginal cancers in women when they got to their 20’s
Taken off market
What is the safe level of alcohol to consume during pregnancy?
NONE
NO KNOWN SAFE LEVEL
Don’t kid yourself with that one glass of red wine shit
Oopsies I have AFib and i take warfarin and now I’m preganant 🤪
what should i take instead?
Heparin
What happens if you take warfarin during preganncy?>
Really really bad. Baby comes out looking really unusual, intellectual disability, and death
What happens if you take thalidomide when you’re pregnant
Your baby comes out with short arms/legs
If you take isotretinoin (Accutane) for your acne, you absolutely can NOT get pregnant. What will your doctor make you do?
Enroll in the iPLEDGE program.
Two forms of birth control one month prior to and one month after isotretinoin
Everybody knows that anticonvulsants are not the best thing to take in pregnancy, but sometimes they are necessary.
Which anticonvulsants have the LOWEST risk during pregnancy?
Levetiracetam
Lamotrigine
Gabapentin
Clonazepam
(ESPECIALLY THE “L” ONES 👍👍👍👍)
