Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm Exam 2 (ASL) > NSAIDs (Shelby 🐈) > Flashcards

NSAIDs (Shelby 🐈) Flashcards

1
Q

Name! That! NSAID!

Relatively short acting
Decreases arachidonic acid bioavailability

A

Diclofenac (Voltaren)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Name! That! NSAID!

Potent, worst side effect profile

A

Indomethacin (Indocin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

a very small portion of acetaminophen is metabolized this way:

A

A small portion is metabolized by the P450 system creating a free radical which is normally conjugated with glutathione and excreted

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How long can a patient be on Ketorolac (Toradol)

A

5 days

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How is Piroxican (Feldene), Meloxicam (Mobic) a better option NSAID for patients with hepatic disease

A

Decreases oxygen radical production

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Effects of acetaminophen in the body

normal doses NOT overdose

A

CNS effects only

no GI problems, no kidney adverse effects, no inhibition of blood clotting like NSAIDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is the main effect of Specific inhibitors of COX-2 enzymes

A

Inhibition of the production of prostacyclin by endothelial cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Name! That! NSAID!

Very potent and very long acting - single daily dosing is possible

A

Naproxen (Naprosyn)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

acetaminophen is MOSTLY metabolized this way:

A

glucoronidated in the liver and excreted by the kidney

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What is Ketorolac (Toradol) used for

A

postsurgical pain

Can be combined with opioids to reduce side effects from opioids (constipation)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

DOC for small children with fever

A

acetaminophen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What does acetaminophen do?

What does it NOT do?

A

Very good analgesic and antipyretic agent

Not an NSAID- does not have an anti-inflammatory effect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Name! That! NSAID!

Not in the US, very potent and effective

A

Phenylbutazone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Why do Specific inhibitors of COX-2 enzymes have less GI side effects than aspirin

A

Reduced effect on GI because they are not inhibiting COX-1, which produces the GI protecting prostaglandins

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Name! That! NSAID!

Can be combined with opioids to reduce side effects from opioids (constipation)

A

Ketorolac (Toradol)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Patient has active PUD, what can you give them?

**********

A

acetaminophen and/or opioids only

NO NSAIDs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Name! That! NSAID!

Decreases oxygen radical production, better for patients with hepatotoxicity

A

Piroxican (Feldene), Meloxicam (Mobic)

18
Q

Name! That! NSAID!

First choice drug, lowest incidence of side effects

A

Ibuprofen (Motrin)

19
Q

Diclofenac (Voltaren) is often combined with _______ to decrease GI side effects

A

misoprostol (Arthrotec)

20
Q

Benefit of Celecoxib (Celebrex)

Downside of Celecoxib (Celebrex)

A

Benefit: Less effect on GI (less cox-1 inhibition)

Downside: increased risk of cardiovascular disease (imbalance of prostacyclin and thromboxane)

21
Q

What happens if glutathione is exhausted in regards to acetaminophen excretion

A

the free radicals will cause severe liver necrosis

22
Q

Name! That! NSAID!

Extensively bound to plasma proteins, displacement causes adverse drug reactions with bound drugs (warfarin, anti-diabetics, etc)

A

Naproxen (Naprosyn)

23
Q

Name! That! NSAID!

Prodrug, long half life

A

Nabumetone (Felafen)

24
Q

acetaminophen overdose antidote:

A

N-acetylcysteine (Mucomyst)

25
Q

Why should patients that are chronic alcoholics NOT take acetaminophen

A

If there is an increased production of the metabolite as in chronic alcoholism, which induces the P450 system, this also leads to severe liver damage

26
Q

acetaminophen overdose causes:

A

fatal hepatic necrosis

27
Q

How does Indomethacin (Indocin) reduce inflammation in addition to being a cox blocker

A

Reduces PMN migration – additional anti-inflammatory effect

Inhibits phospholipase A – decreases synthesis of prostaglandins from arachidonic acid

28
Q

Patient has history of PUD, but it is not currently active. What can you give them
***************

A

Celecoxib with or without antacids or some NSAIDs with Misoprostol or “-prazols”

29
Q

What is the only Specific inhibitor of COX-2 enzymes that is available in the US

A

Celecoxib (Celebrex)

30
Q

What is the major side effect caused by the imbalance between thromboxane and prostacyclin with Specific inhibitors of COX-2 enzymes

A

Excess Thromboxane in the absence of prostacyclin promotes the development of cardiovascular problems

31
Q

Name! That! NSAID!

The reversible binding inhibits the irreversible binding of aspirin – decreases effects on platelet aggregation, should not be combined

A

Ibuprofen (Motrin)

32
Q

No history of PUD

What can you give them
***************

A

any NSAID

33
Q

A 78 year old man is taking daily aspirin for stroke prevention. One day he decides to go to Tijuana to see a donkey show. He has a few margaritas while he is down there and tries to wave down a prostitute on the street at the end of the night. He ends up waving down an undercover Mexican cop and is arrested for the solicitation of a prostitute. The cop suddenly gets the urge that he has to IMMEDIATELY diarrhea from the tacos he hate for dinner. He leaves the man in his unlocked cop car so the old man decides to make a run for it. He leaps across the border and sprains his ankle. He limps into an urgent care and the NP decides not to ask any questions but just give him some Ibuprofen and tell him to get a life. What is going to happen?

A
  1. The ibuprofen is going to INHIBIT the aspirins effect on platelets, and he is going to have a stroke
  2. He is going to have an STI
  3. He is going to get extradited to Mexico to serve time in a Mexican prison, where he will likely get more STIs
34
Q

Name! That! NSAID!

Cannot be used longer than 5 days due to GI side effects

A

Ketorolac (Toradol)

35
Q

Name! That! NSAID!

Long half life
Inhibits PMN migration

and

Lymphocyte function

A

Piroxican (Feldene), Meloxicam (Mobic)

36
Q

Name! That! NSAID!

Potent – can be used for postsurgical pain

A

Ketorolac (Toradol)

37
Q

Name! That! NSAID!
Reduces PMN migration

and

Inhibits phospholipase A

A

Indomethacin (Indocin)

38
Q

Why do you not combine Ibuprofen (Motrin) and Aspirin

A

The reversible binding of Ibuprofen inhibits the irreversible binding of aspirin – decreases effects on platelet aggregation, should not be combined

39
Q

What is the problem with Specific inhibitors of COX-2 enzymes

A

Creates and imbalance between thromboxane and prostacyclin

Excess Thromboxane in the absence of prostacyclin promotes the development of cardiovascular problems

40
Q

Name! That! NSAID!

Used for patent ductus arteriosus

A

Indomethacin (Indocin)

Pharm Exam 2 (ASL) (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions